| 词条 | Myod family inhibitor domain containing |
| 释义 |
MyoD family inhibitor domain containing is a protein that in humans is encoded by the MDFIC gene. [1]FunctionThis gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants. References1. ^{{cite web| title = Entrez Gene: MyoD family inhibitor domain containing| url = https://www.ncbi.nlm.nih.gov/gene/29969| accessdate = 2016-02-09}} Further reading{{refbegin | 2}}{{refend}}{{NLM content}}{{gene-7-stub}}{{protein-stub}} 1 : Human proteins |
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