| 词条 | Nemorexant |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = [(2S)-2-(5-Chloro-4-methyl-1H-benzimidazol-2-yl)-2-methylpyrrolidin-1-yl]-[5-methoxy-2-(triazol-2-yl)phenyl]methanone | image = Nemorexant.svg | width = 250px | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = By mouth | class = Orexin antagonist | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 1505484-82-1 | CAS_supplemental = | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = 91801202 | IUPHAR_ligand = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 64854514 | UNII = LMQ24G57E9 | KEGG = | ChEBI = | ChEMBL = | synonyms = ACT-541468 | C=23 | H=23 | Cl=1 | N=6 | O=2 | molecular_weight = 450.927 g/mol | SMILES = CC1=C(C=CC2=C1N=C(N2)[C@@]3(CCCN3C(=O)C4=C(C=CC(=C4)OC)N5N=CC=N5)C)Cl | StdInChI_Ref = | StdInChI = 1S/C23H23ClN6O2/c1-14-17(24)6-7-18-20(14)28-22(27-18)23(2)9-4-12-29(23)21(31)16-13-15(32-3)5-8-19(16)30-25-10-11-26-30/h5-8,10-11,13H,4,9,12H2,1-3H3,(H,27,28)/t23-/m0/s1 | StdInChIKey_Ref = | StdInChIKey = NBGABHGMJVIVBW-QHCPKHFHSA-N }}Nemorexant (developmental code name ACT-541468) is a dual orexin receptor antagonist (DORA) which was originated by Actelion Pharmaceuticals and is under development by Idorsia Pharmaceuticals for the treatment of insomnia.[1][2] It acts as a selective dual antagonist of the orexin receptors OX1 and OX2.[1][2] As of June 2018, nemorexant is in phase III clinical trials for the treatment of insomnia.[1] See also
References1. ^1 2 https://adisinsight.springer.com/drugs/800044843 2. ^1 {{cite journal | vauthors = Equihua-Benítez AC, Guzmán-Vásquez K, Drucker-Colín R | title = Understanding sleep-wake mechanisms and drug discovery | journal = Expert Opin Drug Discov | volume = 12 | issue = 7 | pages = 643–657 | date = July 2017 | pmid = 28511597 | doi = 10.1080/17460441.2017.1329818 | url = }} External links
9 : Benzimidazoles|Chloroarenes|Ethers|Experimental drugs|Hypnotics|Ketones|Orexin antagonists|Pyrrolidines|Triazoles |
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