| 词条 | New Jersey polyomavirus |
| 释义 |
| name = New Jersey polyomavirus | virus_group = i | familia = Polyomaviridae | genus = Alphapolyomavirus | species = New Jersey polyomavirus }}New Jersey polyomavirus (NJPyV, also known as Human polyomavirus 13) is a virus of the polyomavirus family that infects human hosts. It was first identified in 2014 in a pancreatic transplant patient in New Jersey. It is the 13th and most recent human polyomavirus to be described.[1] DiscoveryNJPyV was first reported in 2014 after it was isolated from epithelial cells of a pancreatic transplant patient presenting with blindness, vasculitis, myopathy, and dermatosis. After doctors were unable to identify known viral causes of the patient's symptoms, a research team led by virologist Ian Lipkin screened samples of affected tissue for the presence of novel viruses, and identified the genome of a novel polyomavirus.[1][2] GenomeThe organization of the NJPyV genome is typical of polyomaviruses. At around 5.1 kilobase pairs in length, it contains six identifiable genes: the small tumor antigen, large tumor antigen, and alternative tumor antigen (ALTO); and three viral coat proteins, VP1, VP2, and VP3.[1] The ALTO protein is an unusual alternative splicing product of the "late region" of the genome, which canonically encodes the small and large tumor antigens; expression of ALTO has also been reported in trichodysplasia spinulosa polyomavirus.[3] TaxonomyIn the 2015 taxonomic update to the polyomavirus group, the International Committee on Taxonomy of Viruses classified NJPyV as a member of the genus Alphapolyomaviridae, whose type species is murine polyomavirus (Mus musculus polyomavirus 1).[4] PrevalenceThe prevalence of NJPyV is unknown, though other human polyomaviruses are fairly common and usually asymptomatic.[5] Only a small number of studies have yet attempted to screen for NJPyV in the general population, and none have reported detecting it.[6][7] It is unclear if the New Jersey index case was newly infected at the time symptoms manifested, or if a latent infection was reactivated in the context of stress and immunosuppression (a known mechanism of pathogenicity for polyomaviruses).[1] Clinical manifestationsNJPyV was discovered in clinical samples from a single patient; outside of this case report, the clinical effects of NJPyV are unknown.[1] References1. ^1 2 3 4 {{cite journal|last1=Mishra|first1=Nischay|last2=Pereira|first2=Marcus|last3=Rhodes|first3=Roy H.|last4=An|first4=Ping|last5=Pipas|first5=James M.|last6=Jain|first6=Komal|last7=Kapoor|first7=Amit|last8=Briese|first8=Thomas|last9=Faust|first9=Phyllis L.|last10=Lipkin|first10=W. Ian|title=Identification of a Novel Polyomavirus in a Pancreatic Transplant Recipient With Retinal Blindness and Vasculitic Myopathy|journal=Journal of Infectious Diseases|date=15 November 2014|volume=210|issue=10|pages=1595–9|doi=10.1093/infdis/jiu250 |pmid=24795478 |pmc=4334791}} {{Human polyomaviruses}}{{Taxonbar|from=Q24809427}}2. ^{{cite journal|last1=DeLuca|first1=Ilana J.|last2=Patel|first2=Vishal Anil|last3=Pereira|first3=Marcus R.|last4=Grossman|first4=Marc E.|title=A new polyomavirus-related dermatosis in a pancreatic transplant patient|journal=JAAD Case Reports|date=November 2015|volume=1|issue=6|pages=S38–S40|doi=10.1016/j.jdcr.2015.09.018 |pmid=27051808 |pmc=4809577 }} 3. ^{{cite journal|last1=van der Meijden|first1=Els|last2=Kazem|first2=Siamaque|last3=Dargel|first3=Christina A.|last4=van Vuren|first4=Nick|last5=Hensbergen|first5=Paul J.|last6=Feltkamp|first6=Mariet C. W.|last7=Imperiale|first7=M. J.|title=Characterization of T Antigens, Including Middle T and Alternative T, Expressed by the Human Polyomavirus Associated with Trichodysplasia Spinulosa|journal=Journal of Virology|date=15 September 2015|volume=89|issue=18|pages=9427–39|doi=10.1128/JVI.00911-15 |pmid=26136575 |pmc=4542345}} 4. ^{{cite journal|last1=Polyomaviridae Study Group of the International Committee on Taxonomy of|first1=Viruses|last2=Calvignac-Spencer|first2=S|last3=Feltkamp|first3=MC|last4=Daugherty|first4=MD|last5=Moens|first5=U|last6=Ramqvist|first6=T|last7=Johne|first7=R|last8=Ehlers|first8=B|title=A taxonomy update for the family Polyomaviridae|journal=Archives of Virology|date=29 February 2016|doi=10.1007/s00705-016-2794-y|pmid=26923930|volume=161|issue=6|pages=1739–50}} 5. ^{{cite journal|last1=Ehlers|first1=Bernhard|last2=Wieland|first2=Ulrike|title=The novel human polyomaviruses HPyV6, 7, 9 and beyond|journal=APMIS|date=August 2013|volume=121|issue=8|pages=783–795|doi=10.1111/apm.12104|pmid=23656581}} 6. ^{{cite journal|last1=Li|first1=Ke|last2=Zhang|first2=Chi|last3=Zhao|first3=Rong|last4=Xue|first4=Ying|last5=Yang|first5=Jian|last6=Peng|first6=Junping|last7=Jin|first7=Qi|title=The prevalence of STL polyomavirus in stool samples from Chinese children|journal=Journal of Clinical Virology|date=May 2015|volume=66|pages=19–23|doi=10.1016/j.jcv.2015.02.017 |pmid=25866330}} 7. ^{{cite journal|last1=Herberhold|first1=Stephan|last2=Hellmich|first2=Martin|last3=Panning|first3=Marcus|last4=Bartok|first4=Eva|last5=Silling|first5=Steffi|last6=Akgül|first6=Baki|last7=Wieland|first7=Ulrike|title=Human polyomavirus and human papillomavirus prevalence and viral load in non-malignant tonsillar tissue and tonsillar carcinoma|journal=Medical Microbiology and Immunology|date=10 November 2016|doi=10.1007/s00430-016-0486-6 |pmid=27832373}} 1 : Polyomaviridae |
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