| 词条 | Nifurtimox/eflornithine |
| 释义 |
| drug_name = | type = combo | component1 = Nifurtimox | class1 = antiparasitic agent | component2 = Eflornithine | class2 = antiparasitic agent | pronounce = | tradename = | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_US = | pregnancy_category= | legal_AU = | legal_AU_comment = | legal_BR = | legal_BR_comment = | legal_CA = | legal_UK = | legal_US = | legal_UN = | legal_NZ = | legal_status = | routes_of_administration = | CAS_number = | ATCvet = | ATC_prefix = | ATC_suffix = | PubChem = | DrugBank = }}Nifurtimox/eflornithine is a combination of two antiparasitic drugs, nifurtimox and eflornithine, used in the treatment of African trypanosomiasis (sleeping sickness).[1][2] It is included in the World Health Organization's Model List of Essential Medicines.[3] A treatment regimen known as nifurtimox-eflornithine combination treatment (NECT) is used in second stage gambiense African trypanosomiasis throughout Africa where the disease is endemic.[4] The regimen involves slow infusion of 400 mg of eflornithine every 12 hours for 7 days combined with 15 mg/kg of nifurtimox orally three times a day for 10 days.[4] References1. ^{{Cite journal | doi = 10.1016/S0140-6736(09)61117-X| title = Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: A multicentre, randomised, phase III, non-inferiority trial| journal = The Lancet| volume = 374| issue = 9683| pages = 56| year = 2009| last1 = Priotto| first1 = Gerardo| last2 = Kasparian| first2 = Serena| last3 = Mutombo| first3 = Wilfried| last4 = Ngouama| first4 = Daniel| last5 = Ghorashian| first5 = Sara| last6 = Arnold| first6 = Ute| last7 = Ghabri| first7 = Salah| last8 = Baudin| first8 = Elisabeth| last9 = Buard| first9 = Vincent| last10 = Kazadi-Kyanza| first10 = Serge| last11 = Ilunga| first11 = Médard| last12 = Mutangala| first12 = Willy| last13 = Pohlig| first13 = Gabriele| last14 = Schmid| first14 = Caecilia| last15 = Karunakara| first15 = Unni| last16 = Torreele| first16 = Els| last17 = Kande| first17 = Victor| url = http://fieldresearch.msf.org/msf/bitstream/10144/72797/1/PIIS014067360961117X.pdf}} 2. ^{{Cite journal | doi = 10.1093/cid/cis886| pmid = 23074318| title = Nifurtimox-Eflornithine Combination Therapy for Second-Stage Gambiense Human African Trypanosomiasis: Médecins Sans Frontières Experience in the Democratic Republic of the Congo| journal = Clinical Infectious Diseases| volume = 56| issue = 2| pages = 195| year = 2013| last1 = Alirol| first1 = Emilie| last2 = Schrumpf| first2 = David| last3 = Amici Heradi| first3 = Josué| last4 = Riedel| first4 = Andrea| last5 = De Patoul| first5 = Catherine| last6 = Quere| first6 = Michel| last7 = Chappuis| first7 = François}} 3. ^{{Cite web | url = http://www.who.int/trypanosomiasis_african/research/combination_treatment/en/ | title = Nifurtimox-eflornithine combination treatment for sleeping sickness (human African trypanosomiasis): WHO wraps up training of key health care personnel | publisher = World Health Organization | date = March 23, 2010}} 4. ^1 {{Cite journal | url = http://cdrwww.who.int/selection_medicines/committees/expert/19/applications/NE_6551_pub1.pdf | doi = 10.2147/RRTM.S34399| title = Monitoring the use of nifurtimox-eflornithine combination therapy (NECT) in the treatment of second stage gambiense human African trypanosomiasis| journal = Research and Reports in Tropical Medicine| pages = 93| year = 2012| last1 = Franco| first1 = Jose| last2 = Pere| first2 = Simarro| last3 = Diarra| last4 = Ruiz-Postigo| last5 = Samo| last6 = Jannin}} 1 : Antiparasitic agents |
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