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词条 Nina Papavasiliou
释义

  1. Education and early career

  2. Research

  3. Award & honors

  4. References

{{Infobox scientist
| name = Nina Papavasiliou
| image = Nina_Papavasiliou_at_The_Rockefeller_University.jpg
| residence = Heidelberg, Germany
| fields = Immunology, Molecular Biology
| workplaces = German Cancer Research Center, Rockefeller University, Yale University
| alma_mater = Rockefeller UniversityOberlin College
| doctoral_advisor = Michel C. Nussenzweig
| awards = Searle Scholar, NIH Director's Transformative Research Project Award, ERC Consolidator Award
}}

Nina Papavasiliou is an immunologist and Helmholtz Professor in the Division of Immune Diversity at the German Cancer Research Center in Heidelberg, Germany. She is also an Adjunct Professor at the Rockefeller University, where she was previously Associate Professor and head of the Laboratory of Lymphocyte Biology. She is best known for her work in the fields of DNA and RNA editing.

Education and early career

Papavasiliou received her Bachelors of Science from Oberlin College in biology in 1992. She then completed her PhD at the Rockefeller University in Michel C. Nussenzweig's Laboratory of Molecular Immunology. There, she began studying how B cell antigen receptors—or antibodies anchored to the cell membrane—undergo mutation so they can specifically recognize a particular antigen and elicit an immune response.[1][2] She followed that interest to the Yale School of Medicine, where she worked as a postdoctoral fellow in the lab of David G. Schatz.[3][4]

Research

Papavasiliou's research centers on demystifying how cells and organisms diversify and expand the information encoded in their genomes, both at the DNA and RNA level. She opened her Laboratory of Lymphocyte Biology at Rockefeller University in 2001 as an Assistant Professor.[5] Much of her group's early work was done in the context of the adaptive immune response, which is able to combat a wide array of pathogens seeking to invade the host by rapidly generating novel antibodies that are able to specifically recognize a given invader. Her group has worked to characterize the activity of an enzyme known as activation-induced cytidine deaminase (AID).[6][7] AID changes cytidine (C) residues to uracil (U) in DNA, which is recognized as DNA damage and repaired in such a way that introduces thymidine (T), effectively mutating Cs to Ts in DNA. The process is known as somatic hypermutation and is how B cells can rapidly introduce DNA mutations into receptors that recognize the invaders, known as antigens. Papavasiliou's lab has worked to understand how AID expression is regulated in the immune system and how AID targets certain genes for mutation.[8][9][10]

Papavasiliou also studies RNA editing in the context of the innate immune response using next-generation sequencing and bioinformatics approaches to identify and characterize RNA editing targets. Her group first identified novel RNA editing targets of APOBEC1, which mutates a cytosine to a uracil in an RNA transcript, and was previously thought to only edit Apolipoprotein B (apoB) in the small intestine.[11] Her group has since moved on to attempt to characterize the potential role APOBEC1-editing may be playing outside of its function with apoB.[12]

Papavasiliou most recently branched out to studying mechanisms of antigenic variation—or how pathogens vary their surface proteins to escape the immune response—using Trypanosoma brucei, the parasite that causes African sleeping sickness, as a model organism. Her group has developed new tools to better understand the dynamics of protein coat switching in trypanosomes, and is working to better understand the mechanisms by which trypanosomes are able to diversify their coat proteins over the course of an infection.[13][14][15]

In 2016, Papavasiliou moved to the German Cancer Research Center to begin her lab in the Division of Immune Diversity with additional support from a European Research Council Consolidator Grant.[16][17]

Award & honors

  • Keck Fellow, 2002[18]
  • Searle Scholar, 2003[19]
  • Sinsheimer Fund Scholar, 2005[20]
  • Thorbecke Award, Society for Leukocyte Biology, 2006[21]
  • The Vilcek Foundation Prize Finalist for Creative Promise in Biomedical Science, 2009[22]
  • National Institutes of Health Director’s Transformative Research Project Award, 2011[23]

References

1. ^{{Cite journal|date=1997-04-01|title=Control of immunoglobulin gene rearrangements in developing B cells|journal=Current Opinion in Immunology|language=en|volume=9|issue=2|pages=233–238|doi=10.1016/S0952-7915(97)80141-0|issn=0952-7915|last1=Papavasiliou|first1=Fotini|last2=Jankovic|first2=Mila|last3=Gong|first3=Shiaoching|last4=Nussenzweig|first4=Michel C.}}
2. ^{{Cite journal|last=Papavasiliou|first=Fotini|last2=Casellas|first2=Rafael|last3=Suh|first3=Heikyung|last4=Qin|first4=Xiao-Feng|last5=Besmer|first5=Eva|last6=Pelanda|first6=Roberta|last7=Nemazee|first7=David|last8=Rajewsky|first8=Klaus|last9=Nussenzweig|first9=Michel C.|date=1997-10-10|title=V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody Responses|journal=Science|language=en|volume=278|issue=5336|pages=298–301|doi=10.1126/science.278.5336.298|issn=0036-8075|pmid=9323210}}
3. ^{{Cite journal|last=Papavasiliou|first=F. Nina|last2=Schatz|first2=David G.|date=November 2000|title=Cell-cycle-regulated DNA double-strand breaks in somatic hypermutation of immunoglobulin genes|journal=Nature|language=En|volume=408|issue=6809|pages=216–221|doi=10.1038/35041599|pmid=11089977|issn=0028-0836}}
4. ^{{Cite journal|last=Papavasiliou|first=F.Nina|last2=Schatz|first2=David G|date=April 2002|title=Somatic Hypermutation of Immunoglobulin Genes|url=https://www.cell.com/cell/fulltext/S0092-8674(02)00706-7|journal=Cell|language=English|volume=109|issue=2|pages=S35–S44|doi=10.1016/S0092-8674(02)00706-7|issn=0092-8674|via=}}
5. ^{{Cite news|url=https://www.rockefeller.edu/our-scientists/tri-institutional-professors/884-f-nina-papavasiliou/|title=F. Nina Papavasiliou - Our Scientists|work=Our Scientists|access-date=2018-07-03|language=en-US}}
6. ^{{Cite journal|last=Dickerson|first=Sarah K.|last2=Market|first2=Eleonora|last3=Besmer|first3=Eva|last4=Papavasiliou|first4=F. Nina|date=2003-05-19|title=AID mediates hypermutation by deaminating single stranded DNA|journal=The Journal of Experimental Medicine|volume=197|issue=10|pages=1291–1296|doi=10.1084/jem.20030481|issn=0022-1007|pmc=2193777|pmid=12756266}}
7. ^{{Cite journal|last=Besmer|first=Eva|last2=Market|first2=Eleonora|last3=Papavasiliou|first3=F. Nina|date=June 2006|title=The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination|journal=Molecular and Cellular Biology|volume=26|issue=11|pages=4378–4385|doi=10.1128/MCB.02375-05|issn=0270-7306|pmc=1489098|pmid=16705187}}
8. ^{{Cite journal|last=Crouch|first=Elizabeth E.|last2=Li|first2=Zhiyu|last3=Takizawa|first3=Makiko|last4=Fichtner-Feigl|first4=Stefan|last5=Gourzi|first5=Polyxeni|last6=Montaño|first6=Carolina|last7=Feigenbaum|first7=Lionel|last8=Wilson|first8=Patrick|last9=Janz|first9=Siegfried|date=2007-05-14|title=Regulation of AID expression in the immune response|journal=The Journal of Experimental Medicine|volume=204|issue=5|pages=1145–1156|doi=10.1084/jem.20061952|issn=0022-1007|pmc=2118564|pmid=17452520}}
9. ^{{Cite journal|last=Teng|first=Grace|last2=Hakimpour|first2=Paul|last3=Landgraf|first3=Pablo|last4=Rice|first4=Amanda|last5=Tuschl|first5=Thomas|last6=Casellas|first6=Rafael|last7=Papavasiliou|first7=F. Nina|date=May 2008|title=MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase|journal=Immunity|volume=28|issue=5|pages=621–629|doi=10.1016/j.immuni.2008.03.015|issn=1097-4180|pmc=2430982|pmid=18450484}}
10. ^{{Cite journal|last=Delker|first=Rebecca K.|last2=Zhou|first2=Yanjiao|last3=Strikoudis|first3=Alexandros|last4=Stebbins|first4=C. Erec|last5=Papavasiliou|first5=F. Nina|date=2013-01-15|title=Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase|journal=Proceedings of the National Academy of Sciences of the United States of America|volume=110|issue=3|pages=1029–1034|doi=10.1073/pnas.1214538110|issn=1091-6490|pmc=3549133|pmid=23277564}}
11. ^{{Cite journal|last=Rosenberg|first=Brad R.|last2=Hamilton|first2=Claire E.|last3=Mwangi|first3=Michael M.|last4=Dewell|first4=Scott|last5=Papavasiliou|first5=F. Nina|date=February 2011|title=Transcriptome-wide sequencing reveals numerous APOBEC1 mRNA-editing targets in transcript 3' UTRs|journal=Nature Structural & Molecular Biology|volume=18|issue=2|pages=230–236|doi=10.1038/nsmb.1975|issn=1545-9985|pmc=3075553|pmid=21258325}}
12. ^{{Cite journal|last=Rayon-Estrada|first=Violeta|last2=Harjanto|first2=Dewi|last3=Hamilton|first3=Claire E.|last4=Berchiche|first4=Yamina A.|last5=Gantman|first5=Emily Conn|last6=Sakmar|first6=Thomas P.|last7=Bulloch|first7=Karen|last8=Gagnidze|first8=Khatuna|last9=Harroch|first9=Sheila|date=December 12, 2017|title=Epitranscriptomic profiling across cell types reveals associations between APOBEC1-mediated RNA editing, gene expression outcomes, and cellular function|journal=Proceedings of the National Academy of Sciences of the United States of America|volume=114|issue=50|pages=13296–13301|doi=10.1073/pnas.1714227114|issn=1091-6490|pmc=5740640|pmid=29167373}}
13. ^{{Cite news|url=https://www.sciencedaily.com/releases/2009/04/090415141210.htm|title=Parasite Breaks Its Own DNA To Avoid Detection|work=ScienceDaily|access-date=2018-07-03|language=en}}
14. ^{{Cite web|url=https://www.eurekalert.org/pub_releases/2015-12/ru-ssn120415.php|title=Study suggests new way to help the immune system fight off sleeping sickness parasite|website=EurekAlert!|language=en|access-date=2018-07-03}}
15. ^{{Cite web|url=https://www.eurekalert.org/pub_releases/2015-12/p-ssn120415.php|title=Study suggests new way to help the immune system fight off parasite|website=EurekAlert!|language=en|access-date=2018-07-03}}
16. ^{{Cite web|url=https://www.dkfz.de/en/immundiversitaet/index.php|title=Immune Diversity|website=www.dkfz.de|language=en|access-date=2018-07-03}}
17. ^{{Cite news|url=https://erc.europa.eu/projects-figures/erc-funded-projects/results?search_api_views_fulltext=papavasiliou|title=ERC FUNDED PROJECTS|work=ERC: European Research Council|access-date=2018-07-03|language=en}}
18. ^{{Cite news|url=https://www.rockefeller.edu/our-scientists/visiting-professors/884-f-nina-papavasiliou/|title=F. Nina Papavasiliou - Our Scientists|work=Our Scientists|access-date=2018-10-10|language=en-US}}
19. ^{{Cite web|url=http://www.searlescholars.net/person/88|title=Searle Scholars Program : F. Nina Papavasiliou (2003)|website=www.searlescholars.net|language=en|access-date=2018-07-03}}
20. ^{{Cite news|url=https://www.rockefeller.edu/our-scientists/visiting-professors/884-f-nina-papavasiliou/|title=F. Nina Papavasiliou - Our Scientists|work=Our Scientists|access-date=2018-10-10|language=en-US}}
21. ^{{Cite web|url=https://www.leukocytebiology.org/g-jeanette-thorbecke-award|title=G. Jeanette Thorbecke Award|last=Holland|first=Jennifer|website=www.leukocytebiology.org|language=en-us|access-date=2018-07-03}}
22. ^{{Cite web|url=http://www.vilcek.org/prizes/prize-recipients/2009/finalists.html|title=The Vilcek Foundation - Finalists|website=www.vilcek.org|access-date=2018-07-03}}
23. ^{{Cite web|url=https://projectreporter.nih.gov/project_info_description.cfm?projectnumber=1R01AI097127-01|title=Project Information - NIH RePORTER - NIH Research Portfolio Online Reporting Tools Expenditures and Results|last=generator|first=metatags|website=projectreporter.nih.gov|language=en|access-date=2018-07-03}}
{{Authority control}}{{DEFAULTSORT:Papavasiliou, Nina}}

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