Nissen is a surname. As a Danish surname it is a patronymic meaning "son of Nis" (Danish short form of Nicholas). Notable people with the surname include:

• Georg Nikolaus von Nissen (1761–1826), Danish diplomat and writer, and author of one of the first biographies of Wolfgang Amadeus Mozart
• Peter Norman Nissen (1871–1930), Canadian mining engineer
• Hans-Hermann Nissen (1893-1980), German bass-baritone
• Rudolph Nissen (1896–1981), German surgeon and inventor of the Nissen fundoplication
• George Nissen (1914-2010) inventor of the modern trampoline
• Henry Nissen (born 1948 as Henry Nissenbaum), German/Australian boxer of the 1970s
• Steven E. Nissen (born 1949), heart specialist and chairman of cardiovascular medicine at the Cleveland Clinic
• Christopher Nissen (born 1992), Danish singer
• Tom Nissen (born 1971), American convicted murderer and character in the 1999 film Boys Don't Cry

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