| 词条 | Nitroxinil |
| 释义 |
| drug_name = | INN = | type = | IUPAC_name = 4-Hydroxy-3-iodo-5-nitrobenzonitrile | image = Nitroxinil.png | alt = | caption = Structure of nitroxinil | pronounce = | tradename = Fluconix, Dovenix, Trodax | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_US = | pregnancy_category= | routes_of_administration = Subcutaneous in the form of an N-Ethylgucamine salt solution | legal_AU = | legal_AU_comment = | legal_BR = | legal_BR_comment = | legal_CA = | legal_DE = | legal_NZ = | legal_UK = | legal_US = | legal_UN = | legal_status = | bioavailability = | protein_bound = | metabolism = | metabolites = | onset = | elimination_half-life = | duration_of_action = | excretion = | CAS_number = 1689-89-0 | class = | ATCvet = yes | ATC_prefix = P52 | ATC_suffix = AG08 | PubChem = 15532 | DrugBank = | synonyms = Nitroxynil | UNII = 9L0EXQ7125 | C=7|H=3|I=1|N=2|O=3 | SMILES = C1=C(C=C(C(=C1[N+](=O)[O-])O)I)C#N | StdInChI = 1S/C7H3IN2O3/c8-5-1-4(3-9)2-6(7(5)11)10(12)13/h1-2,11H | melting_point = 136-139 }} Nitroxinil is an anthelmintic, a veterinary medicine against parasitic worms in sheep and cattle. The substance is active against the liver fluke the Fasciola hepatica and to a lesser extent against thread worms in the gastrointestinal tract.[1] Brand names include Fluconix, Dovenix and Trodax. Nitroxynil is also used against strains of the red gum worm (Haemonchus contortus) that have become resistant to benzimidazoles. Nitroxinil was invented by May & Baker[2] in the mid 1960s as part of a program into investigation of derivatives of p-hydroxybenzonitrile. In addition to Nitroxynil, the herbicides ioxynil (3,5-diiodo) and bromoxynil (3,5-dibromo) were also invented by the same company. Nitroxynil has a nitro group in addition to a single iodine group. Nitroxynil is almost insoluble in water. It is usually injected subcutaneously into the animals in the form of the water-soluble ethylglucamine salt.[1] It must not be administered to animals that produce milk for human consumption.[3] References1. ^1 {{cite web|url=http://parasitipedia.net/index.php?option=com_content&view=article&id=2510&Itemid=2783|title=NITROXINIL = NITROXYNIL for veterinary use in CATTLE, SHEEP and GOATS against flukes and roundworms|accessdate=4 April 2018}} 2. ^{{Citation| inventor-last = May & Baker| inventor-first = | inventorlink =| inventor2-last =| inventor2-first =| inventorlink2 =| publication-date = 18 Dec 1964 | issue-date = 6 Mar 1968| title = Method for the Treatment of Helminth Infestations| country-code = GB | patent-number = 1104885}} 3. ^{{cite web|url=http://www.emea.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500015185.pdf|title=Committee for Veterinary Medicinal Products, Nitroxinil, Summary Report|date=June 1998|publisher=The European Agency for the Evaluation of Medical Products|page=5|language=English|accessdate=4 April 2018}} External links
6 : Antiparasitic agents|Veterinary drugs|Phenols|Nitro compounds|Iodoarenes|Nitriles |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。