| 词条 | Norgestomet |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = [(8R,9S,10R,11S,13S,14S,17R)-17-acetyl-11,13-dimethyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate | image = Norgestomet.svg | width = 225px | tradename = Syncro-Mate B, Crestar | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | class = Progestin; Progestogen; Progestogen ester | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 25092-41-5 | CAS_supplemental = | ATC_prefix = | ATC_suffix = | PubChem = 9820838 | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 7996587 | UNII = 3L33UD42X4 | synonyms = Norgestamet; SC-21009; 11β-Methyl-17α-acetoxy-19-norprogesterone; 17α-Hydroxy-11β-methyl-19-norpregn-4-ene-3,20-dione acetate | C=23 | H=32 | O=4 | molecular_weight = 372.498 g/mol | SMILES = CC1CC2(C(CCC2(C(=O)C)OC(=O)C)C3C1C4CCC(=O)C=C4CC3)C | StdInChI = 1S/C23H32O4/c1-13-12-22(4)20(9-10-23(22,14(2)24)27-15(3)25)19-7-5-16-11-17(26)6-8-18(16)21(13)19/h11,13,18-21H,5-10,12H2,1-4H3/t13-,18-,19-,20-,21+,22-,23-/m0/s1 | StdInChIKey = IWSXBCZCPVUWHT-VIFKTUCRSA-N }}Norgestomet, or norgestamet, sold under the brand name Syncro-Mate B and Crestar, is a progestin medication which is used in veterinary medicine to control estrus and ovulation in cattle.[1][2] UsesVeterinaryNorgestomet is used in veterinary medicine. PharmacologyPharmacodynamicsNorgestomet is a progestogen. In addition to the progesterone receptor, it possesses weak (micromolar) affinity for the glucocorticoid receptor.[3] Chemistry{{See also|List of progestogens|Progestogen ester|List of progestogen esters}}Norgestomet, also known as 11β-methyl-17α-acetoxy-19-norprogesterone or as 17α-hydroxy-11β-methyl-19-norpregn-4-ene-3,20-dione acetate, is a synthetic norpregnane steroid and a derivative of progesterone.[1][5] HistoryNorgestomet was developed and introduced for veterinary use in the mid-1970s.[4] Society and cultureGeneric namesNorgestomet is the generic name of the drug and its {{abbrlink|INN|International Nonproprietary Name}}, {{abbrlink|USAN|United States Adopted Name}}, and {{abbrlink|BAN|British Approved Name}}.[1][5] It also known as norgestamet and is known by its developmental code name SC-21009.[1][5][6]Brand namesNorgestomet is marketed under the brand names Syncro-Mate B and Crestar.[1][5] References1. ^1 2 3 4 {{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA887|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=887–}} {{Progestogens and antiprogestogens}}{{Progesterone receptor modulators}}{{Glucocorticoid receptor modulators}}2. ^{{cite book|author1=Charles G. Gebelein|author2=Richard L. Dunn|title=Progress in Biomedical Polymers|url=https://books.google.com/books?id=-qXTBH9-an0C&pg=PA356|date=1 July 1990|publisher=Springer Science & Business Media|isbn=978-0-306-43523-2|pages=356–}} 3. ^{{cite journal | vauthors = Moffatt RJ, Zollers WG, Welshons WV, Kieborz KR, Garverick HA, Smith MF | title = Basis of norgestomet action as a progestogen in cattle | journal = Domest. Anim. Endocrinol. | volume = 10 | issue = 1 | pages = 21–30 | year = 1993 | pmid = 8467644 | doi = | url = }} 4. ^{{cite book|author=I. Gordon|title=Controlled Breeding in Farm Animals|url=https://books.google.com/books?id=mEgvBQAAQBAJ&pg=PA40|date=22 October 2013|publisher=Elsevier|isbn=978-1-4832-8569-6|pages=40–}} 5. ^1 2 3 https://www.drugs.com/international/norgestomet.html 6. ^http://krex.k-state.edu/dspace/handle/2097/27088 8 : Acetate esters|Alcohols|Diketones|Glucocorticoids|Norpregnanes|Progestogen esters|Progestogens|Veterinary drugs |
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