| 词条 | Normustine |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = Bis(2-chloroethyl)carbamic acid | image = Normustine.svg | width = 225px | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 78619-95-1 | CAS_supplemental = | class = | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = 18377863 | IUPHAR_ligand = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = | UNII = Q2KPX8TH4K | KEGG = | ChEBI = | ChEMBL = | C=5 | H=9 | Cl=2 | N=1 | O=2 | molecular_weight = 186.032 g/mol | SMILES = C(CCl)N(CCCl)C(=O)O | StdInChI_Ref = | StdInChI = 1S/C5H9Cl2NO2/c6-1-3-8(4-2-7)5(9)10/h1-4H2,(H,9,10) | StdInChIKey_Ref = | StdInChIKey = TTYAKTJQJVVKED-UHFFFAOYSA-N | synonyms = Bis(2-chloroethyl)carbamic acid }}Normustine, also known as bis(2-chloroethyl)carbamic acid, is a nitrogen mustard and alkylating antineoplastic agent (i.e., chemotherapy agent).[1][2][3] It is a metabolite of a number of antineoplastic agents that have been developed for the treatment of tumors, including estramustine phosphate, alestramustine, cytestrol acetate, and ICI-85966 (stilbostat), but only the former of which has actually been marketed.[1][2][3] References1. ^1 {{cite book|author1=Laurence Brunton|author2=Bruce Chabner|author3=Bjorn Knollman|title=Goodman and Gilman's The Pharmacological Basis of Therapeutics, Twelfth Edition|url=https://books.google.com/books?id=e_yAOpyyaowC|date=14 January 2011|publisher=McGraw Hill Professional|isbn=978-0-07-176939-6|page=1709}} {{Chemotherapeutic agents}}{{Antineoplastic-drug-stub}}2. ^1 {{cite book|author1=Brian W. Fox|author2=M. Fox|title=Antitumor Drug Resistance|url=https://books.google.com/books?id=m-TrCAAAQBAJ&pg=PA199|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-3-642-69490-5|pages=199–}} 3. ^1 {{cite book|author=Michael Decker|title=Design of Hybrid Molecules for Drug Development|url=https://books.google.com/books?id=gfEbDQAAQBAJ&pg=PA201|date=5 April 2017|publisher=Elsevier Science|isbn=978-0-08-101118-8|pages=201–}} 6 : Alkylating antineoplastic agents|Carbamates|Human drug metabolites|Nitrogen mustards|Organochlorides|Chloroethyl compounds |
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