“Nuclear calcium”的意思、由来-开放百科全书

The concentration of calcium in the cell nucleus can increase in response to signals from the environment. Nuclear calcium is an evolutionary conserved potent regulator of gene expression that allows cells to undergo long-lasting adaptive responses. The 'Nuclear Calcium Hypothesis’ by Hilmar Bading describes nuclear calcium in neurons as an important signaling end-point in synapse-to-nucleus communication that activates gene expression programs needed for persistent adaptations.^[1] In the nervous system, nuclear calcium is required for long-term memory formation, acquired neuroprotection, and the development of chronic inflammatory pain.^[2]^[3]^[4]^[5] In the heart, nuclear calcium is important for the development of cardiac hypertrophy.^[6]^[7] In the immune system, nuclear calcium is required for human T cell activation.^[8] Plants use nuclear calcium to control symbiosis signaling.^[9]

1. ^{{Cite journal|last=Bading|first=H.|date=2000-09-01|title=Transcription-dependent neuronal plasticity: the nuclear calcium hypothesis|journal=European Journal of Biochemistry / FEBS|volume=267|issue=17|pages=5280–5283|doi=10.1046/j.1432-1327.2000.01565.x|issn=0014-2956|pmid=10951185}}
2. ^{{Cite journal|last=Weislogel|first=Jan-Marek|last2=Bengtson|first2=C. Peter|last3=Müller|first3=Michaela K.|last4=Hörtzsch|first4=Jan N.|last5=Bujard|first5=Martina|last6=Schuster|first6=Christoph M.|last7=Bading|first7=Hilmar|date=2013-05-07|title=Requirement for nuclear calcium signaling in Drosophila long-term memory|journal=Science Signaling|volume=6|issue=274|pages=ra33|doi=10.1126/scisignal.2003598|issn=1937-9145|pmid=23652205}}
3. ^{{Cite journal|last=Zhang|first=Sheng-Jia|last2=Zou|first2=Ming|last3=Lu|first3=Li|last4=Lau|first4=David|last5=Ditzel|first5=Désirée A. W.|last6=Delucinge-Vivier|first6=Celine|last7=Aso|first7=Yoshinori|last8=Descombes|first8=Patrick|last9=Bading|first9=Hilmar|date=2009-08-01|title=Nuclear calcium signaling controls expression of a large gene pool: identification of a gene program for acquired neuroprotection induced by synaptic activity|journal=PLOS Genetics|volume=5|issue=8|pages=e1000604|doi=10.1371/journal.pgen.1000604|issn=1553-7404|pmc=2718706|pmid=19680447}}
4. ^{{Cite journal|last=Simonetti|first=Manuela|last2=Hagenston|first2=Anna M.|last3=Vardeh|first3=Daniel|last4=Freitag|first4=H. Eckehard|last5=Mauceri|first5=Daniela|last6=Lu|first6=Jianning|last7=Satagopam|first7=Venkata P.|last8=Schneider|first8=Reinhard|last9=Costigan|first9=Michael|date=2013-01-09|title=Nuclear calcium signaling in spinal neurons drives a genomic program required for persistent inflammatory pain|journal=Neuron|volume=77|issue=1|pages=43–57|doi=10.1016/j.neuron.2012.10.037|issn=1097-4199|pmc=3593630|pmid=23312515}}
5. ^{{Cite journal|last=Bading|first=Hilmar|title=Nuclear calcium signalling in the regulation of brain function|journal=Nature Reviews Neuroscience|volume=14|issue=9|pages=593–608|doi=10.1038/nrn3531|pmid=23942469|year=2013}}
6. ^{{Cite journal|last=Higazi|first=Daniel R.|last2=Fearnley|first2=Claire J.|last3=Drawnel|first3=Faye M.|last4=Talasila|first4=Amarnath|last5=Corps|first5=Elaine M.|last6=Ritter|first6=Oliver|last7=McDonald|first7=Fraser|last8=Mikoshiba|first8=Katsuhiko|last9=Bootman|first9=Martin D.|date=2009-02-27|title=Endothelin-1-stimulated InsP3-induced Ca2+ release is a nexus for hypertrophic signaling in cardiac myocytes|journal=Molecular Cell|volume=33|issue=4|pages=472–482|doi=10.1016/j.molcel.2009.02.005|issn=1097-4164|pmid=19250908}}
7. ^{{Cite journal|last=Guatimosim|first=Silvia|last2=Amaya|first2=Maria Jimena|last3=Guerra|first3=Mateus T.|last4=Aguiar|first4=Carla J.|last5=Goes|first5=Alfredo M.|last6=Gómez-Viquez|first6=Norma Leticia|last7=Rodrigues|first7=Michele A.|last8=Gomes|first8=Dawidson A.|last9=Martins-Cruz|first9=Juliana|date=2008-08-01|title=Nuclear Ca2+ regulates cardiomyocyte function|journal=Cell Calcium|volume=44|issue=2|pages=230–242|doi=10.1016/j.ceca.2007.11.016|issn=0143-4160|pmid=18201761}}
8. ^{{Cite journal|last=Monaco|first=Sara|last2=Jahraus|first2=Beate|last3=Samstag|first3=Yvonne|last4=Bading|first4=Hilmar|date=2016-10-24|title=Nuclear calcium is required for human T cell activation|url=http://jcb.rupress.org/content/215/2/231|journal=J Cell Biol|language=en|volume=215|issue=2|pages=231–243|doi=10.1083/jcb.201602001|issn=0021-9525|pmc=5084645|pmid=27810914}}
9. ^{{Cite journal|last=Oldroyd|first=Giles E. D.|last2=Downie|first2=J. Allan|date=2006-08-01|title=Nuclear calcium changes at the core of symbiosis signalling|journal=Current Opinion in Plant Biology|volume=9|issue=4|pages=351–357|doi=10.1016/j.pbi.2006.05.003|issn=1369-5266|pmid=16713329}}

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