| 词条 | Ovandrotone albumin |
| 释义 |
| type = combo | drug_name = | component1 = Ovandrotone | class1 = Androstane steroid | component2 = Human serum albumin | class2 = Serum protein | tradename = Fecundin, Ovastim | Drugs.com = {{drugs.com|monograph|estrogen-progestin-combinations}} | MedlinePlus = | licence_EU = | licence_US = | DailyMedID = | pregnancy_AU = | pregnancy_US = X | pregnancy_category= | legal_AU = | legal_CA = | legal_UK = | legal_US = Rx-only | legal_status = | routes_of_administration = | CAS_number = | CAS_supplemental = | ATCvet = | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = | PubChemSubstance = | IUPHAR_ligand = | DrugBank = | ChemSpiderID = None | UNII = | KEGG = | ChEBI = | ChEMBL = | synonyms = Polyandroalbumin; GR-33207; Ovandrotone:human serum albumin conjugate }}Ovandrotone albumin ({{abbrlink|INN|International Nonproprietary Name}}, {{abbrlink|BAN|British Approved Name}}) (brand names Fecundin, Ovastim),[1] also known as polyandroalbumin, as well as ovandrotone:human serum albumin conjugate, is an immunogen and vaccine against androstenedione that is used in veterinary medicine to increase the ovulation rate and number of lambs born to ewes.[2][3][4][5] It is a conjugate of ovandrotone (androstenedione-7α-carboxyethylthioether)[6] and human serum albumin.[5] The drug was developed by 1981 and was introduced in Australia and New Zealand in 1983.[4][9] Ovandrotone albumin produces transient immunity against androstenedione,[7] and the generation of antibodies against androstenedione presumably decreases circulating levels of androstenedione.[8] This is thought to result in reduced negative feedback on the hypothalamic-pituitary-gonadal axis and increased gonadotropin secretion, which in turn improves fertility and fecundity.[4] Indeed, ovandrotone albumin has been found to significantly increase luteinizing hormone levels throughout the estrous cycle in ewes.[4] See also
References1. ^{{cite book|author1=R. Sylvester-Bradley|author2=Julian Wiseman|title=Yields of Farmed Species: Constraints and Opportunities in the 21st Century|url=https://books.google.com/books?id=gnUbAQAAMAAJ|date=1 January 2005|publisher=Nottingham University Press|isbn=978-1-904761-23-5|page=55}} {{Androgens and antiandrogens}}{{Estrogens and antiestrogens}}{{Vaccines}}{{genito-urinary-drug-stub}}2. ^{{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=RA1-PA908|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|page=908}} 3. ^{{cite journal|last1=Hoskinson|first1=R. M.|last2=Scaramuzzi|first2=R. J.|last3=Campbell|first3=B. K.|last4=Downing|first4=J. A.|last5=Welch|first5=R. J.|last6=Harrison|first6=B. E.|title=Effects of Antibodies to Steroid Hormones on Reproductive Events of Sheep and Cattle|year=1986|pages=351–366|doi=10.1007/978-1-4684-5140-5_38}} 4. ^1 2 3 {{cite journal|last1=Carnegie|first1=Patrick R.|title=Autoimmunization Against Hormones: A New Strategy in Animal Production|year=1988|pages=245–254|doi=10.1007/978-1-4612-3734-1_15}} 5. ^1 International Nonproprietary Names (INN) for biological and biotechnological substances 6. ^{{cite book|title=Journal of Animal Science|url=https://books.google.com/books?id=nbqzAAAAIAAJ|year=1991|publisher=American Society of Animal Science|pages=3931–3932}} 7. ^Lindsay, D. R., & Pearce, D. T. (Eds.). (1984). Reproduction in Sheep. Cambridge University Press. 8. ^1 {{cite book|author1=J.M. Sreenan|author2=M.G. Diskin|title=Embryonic Mortality in Farm Animals|url=https://books.google.com/books?id=QKFyBgAAQBAJ&pg=PA172|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-94-009-5038-2|pages=172–}} 4 : Combination drugs|Progonadotropins|Vaccines|Veterinary drugs |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。