词条 | AIDS Clinical Trials Group |
释义 |
The AIDS Clinical Trials Group network (ACTG) is one of the largest HIV clinical trials organizations in the world, playing a major role in setting standards of care for HIV infection and opportunistic diseases related to HIV and AIDS in the United States and the developing world. The ACTG is composed of, and directed by, leading clinical scientists in HIV/AIDS therapeutic research. The ACTG is funded by the Department of Health and Human Services, National Institutes of Health through the National Institute of Allergy and Infectious Diseases. MissionThrough innovative studies of the treatment of HIV-1 infection and its complications, ACTG research focuses on:
HistoryThe ACTG has been pivotal{{citation needed|date=October 2013}} in providing the data necessary for the approval of therapeutic agents, as well as treatment and prevention strategies, for many opportunistic infections and malignancies. In 1986, the original AIDS Treatment and Evaluation Units were established by the National Institutes of Health. In 1987, the AIDS Clinical Trials Group (ACTG) was established by the National Institute of Allergy and Infectious Diseases. In 1991, the ACTG divided its focus into two groups and created the Adult ACTG (AACTG) and the Pediatric ACTG (PACTG). In 1995 the AACTG restructured and created a true self-governing structure, with self-evaluation of sites, priority setting of scientific research, discretionary spending. The PACTG became its own group and an AIDS Malignancy Consortium was established under the National Cancer Institute. In 1999 the AACTG applied for continued funding as an investigator led and run group In 2000, the AACTG began the planning and development of international research initiatives in the developing world. In 2005, the ACTG opened its first multinational AIDS clinical trial in 16 sites around the globe “A Phase IV, Prospective, Randomized, Open-Label Evaluation of the Efficacy of Once-Daily PI & Once-Daily Non-Nucleoside Reverse Transcriptase Inhibitor - Containing Therapy Combinations for Initial Treatment of HIV-1 Infected individuals from Resource - Limited Settings (PEARLS) Trial”, the results of which suggested men and women respond to antiretroviral drugs differently.[1] In 2006, the network was funded as one of the six NIAID-funded HIV/AIDS Clinical Trials Networks.[2] Scientific accomplishments
Strategies for sequencing of regimens or enhancing their activity Evaluation of approaches to salvage therapy Evaluation of novel immune-based therapies using interferons, GM-CSF, G-CSF, thalidomide, IL-2, IL-12, cyclosporin (CsA), prednisone, cytotoxic agents, therapeutic immunization
Pneumocystis carinii pneumonia Cytomegalovirus retinitis Cryptococcal meningitis Toxoplasmic encephalitis Hepatitis B and Hepatitis C Histoplasmosis Herpes virus infections Mycobacterium avium complex disease Tuberculosis
References1. ^{{Cite journal | last1 = Campbell | first1 = T. B. | last2 = Smeaton | first2 = L. M. | last3 = Kumarasamy | first3 = N. | last4 = Flanigan | first4 = T. | last5 = Klingman | first5 = K. L. | last6 = Firnhaber | first6 = C. | last7 = Grinsztejn | first7 = B. | last8 = Hosseinipour | first8 = M. C. | last9 = Kumwenda | first9 = J. | last10 = Lalloo | first10 = U. | last11 = Riviere | first11 = C. | last12 = Sanchez | first12 = J. | last13 = Melo | first13 = M. | last14 = Supparatpinyo | first14 = K. | last15 = Tripathy | first15 = S. | last16 = Martinez | first16 = A. I. | last17 = Nair | first17 = A. | last18 = Walawander | first18 = A. | last19 = Moran | first19 = L. | last20 = Chen | first20 = Y. | last21 = Snowden | first21 = W. | last22 = Rooney | first22 = J. F. | last23 = Uy | first23 = J. | last24 = Schooley | first24 = R. T. | last25 = De Gruttola | first25 = V. | last26 = Hakim | first26 = J. G. | author27 = for the PEARLS study team of the ACTG and PEARLS study team of the ACTGG | editor1-last = Deeks | editor1-first = Steven G | title = Efficacy and Safety of Three Antiretroviral Regimens for Initial Treatment of HIV-1: A Randomized Clinical Trial in Diverse Multinational Settings | doi = 10.1371/journal.pmed.1001290 | journal = PLoS Medicine | volume = 9 | issue = 8 | pages = e1001290 | year = 2012 | pmid = 22936892| pmc =3419182 }} 2. ^{{cite web |url= http://www.niaid.nih.gov/news/qa/pages/leadershipqa.aspx |title=Q & A: Leadership for the Newly Reorganized NIAID HIV/AIDS |first= |last= |work=niaid.nih.gov |date=June 29, 2006 |accessdate=11 September 2012}} External links{{official website|https://actgnetwork.org/}}{{AIDS}}{{DEFAULTSORT:Aids Clinical Trials Group}} 2 : United States Department of Health and Human Services|HIV/AIDS organizations |
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