Paterno is a surname. Notable people with the surname include:

• Charles V. Paterno (1876–1946), American real estate developer
• Dolores Paterno (1854–1881), Filipina composer, sister of Pedro Paterno
• Emanuele Paternò (1847–1935), Italian chemist
• Fabio Paternò, Italian computer scientist
• Joe Paterno (1926–2012), American college football coach
• Jay Paterno, Joe Paterno's son and former assistant coach to his father
• Pedro Paterno (1857–1911), Filipino politician, poet, and novelist; brother of Dolores Paterno

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