Pedrazzini is an Italian surname. Notable people with the surname include:

• Fabrizio Pedrazzini (born 1979), Italian ice dancer
• Giuseppe Pedrazzini (1879–1957), Italian luthier
• Luigi Pedrazzini (footballer) (born 1909), Italian footballer
• Massimo Pedrazzini (born 1958), Italian footballer and manager
• Mauro Pedrazzini (born 1965), Liechtenstein politician

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