| 词条 | Peforelin |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = (3S)-4-[[(2S)-1-[[(2S)-6-amino-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-[[(2S)-2-[[(2S)-3-hydroxy-2-[[(2S)-2-[[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-oxobutanoic acid | image = Peforelin.svg | width = 250px | tradename = Maprelin | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = Injection | class = GnRH agonist | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 147859-97-0 | CAS_supplemental = | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = 16197823 | IUPHAR_ligand = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 17326238 | UNII = UJ8NQ5Z0VX | KEGG = | ChEBI = | ChEMBL = | synonyms = Lamprey GnRH-III; H-Pyr-His-Trp-Ser-His-Asp-Trp-Lys-Pro-Gly-NH{{Sub|2}}; XHWSHDWKPG | C=59 | H=74 | N=18 | O=14 | molecular_weight = 1259.353 g/mol | SMILES = C1C[C@H](N(C1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC4=CN=CN4)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8)C(=O)NCC(=O)N | StdInChI_Ref = | StdInChI = 1S/C59H74N18O14/c60-16-6-5-12-40(59(91)77-17-7-13-47(77)58(90)66-27-48(61)79)70-52(84)41(18-31-23-64-37-10-3-1-8-35(31)37)72-56(88)45(22-50(81)82)75-55(87)44(21-34-26-63-30-68-34)74-57(89)46(28-78)76-53(85)42(19-32-24-65-38-11-4-2-9-36(32)38)71-54(86)43(20-33-25-62-29-67-33)73-51(83)39-14-15-49(80)69-39/h1-4,8-11,23-26,29-30,39-47,64-65,78H,5-7,12-22,27-28,60H2,(H2,61,79)(H,62,67)(H,63,68)(H,66,90)(H,69,80)(H,70,84)(H,71,86)(H,72,88)(H,73,83)(H,74,89)(H,75,87)(H,76,85)(H,81,82)/t39-,40-,41-,42-,43-,44-,45-,46-,47-/m0/s1 | StdInChIKey_Ref = | StdInChIKey = RTASYRSYWSLWJV-CSYZDTNESA-N }}Peforelin ({{abbrlink|INN|International Nonproprietary Name}}), or peforelin acetate, sold under the brand name Maprelin, is a gonadotropin-releasing hormone agonist (GnRH agonist) medication which is used in veterinary medicine in Europe and Canada.[1][2][3][4] It is a GnRH analogue and a synthetic peptide, specifically a decapeptide.[1][3][4] The drug was introduced for veterinary use by 2001.[5] See also
References1. ^1 https://www.drugs.com/international/peforelin.html {{GnRH and gonadotropins}}{{GnRH and gonadotropin receptor modulators}}{{Drug-stub}}2. ^https://www.drugs.com/vet/maprelin-xp-10-can.html 3. ^1 {{cite book|author1=Wolfgang Löscher|author2=Angelika Richter|author3=Heidrun Potschka|title=Pharmakotherapie bei Haus- und Nutztieren: Begründet von W. Löscher, F.R. Ungemach und R. Kroker|url=https://books.google.com/books?id=g1ldBAAAQBAJ&pg=PA435|date=3 September 2014|publisher=Enke|isbn=978-3-8304-1251-9|pages=435–}} 4. ^1 {{cite book|author=Heriberto Rodriguez-Martinez|title=Control of Pig Reproduction VIII|url=https://books.google.com/books?id=em-TrWgAFSYC&pg=PA190|date=1 April 2010|publisher=Nottingham University Press|isbn=978-1-907284-53-3|pages=190–}} 5. ^http://www.sgau.ru/files/pages/846/14713368000.pdf#page=48 3 : GnRH agonists|Peptides|Veterinary drugs |
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