词条 | Peptidoglycan recognition protein |
释义 |
StructurePGRPs contain at least one C-terminal peptidoglycan recognition domain, which is about 165 amino acids long. This peptidoglycan-binding type 2 amidase domain is homologous to bacteriophage and bacterial type 2 amidases.[3] TypesInsects generate up to 19 alternatively spliced PGRPs, classified into long (L) and short (S) forms. For instance, the fruit fly (Drosophila melanogaster) expresses 13 PGRPs which are alternatively spliced into 19 proteins, while the mosquito (Anopheles gambiae) expresses 7 PGRPs, with 9 splice variants.[1] Mammals have up to four PGRPs, all of which are secreted. These are peptidoglycan recognition protein 1 (PGLYRP1), peptidoglycan recognition protein 2 (PGLYRP2), peptidoglycan recognition protein 3 (PGLYRP3) and peptidoglycan recognition protein 4 (PGLYRP4).[2] References1. ^1 {{cite journal|last1=Royet|first1=Julien|last2=Gupta|first2=Dipika|last3=Dziarski|first3=Roman|title=Peptidoglycan recognition proteins: modulators of the microbiome and inflammation|journal=Nature Reviews Immunology|date=11 November 2011|doi=10.1038/nri3089|pmid=22076558|volume=11|pages=837–51}} 2. ^1 2 {{cite journal|last1=Dziarski|first1=R|title=Peptidoglycan recognition proteins (PGRPs)|journal=Molecular Immunology|date=February 2004|volume=40|issue=12|pages=877–886|doi=10.1016/j.molimm.2003.10.011}} 3. ^{{cite journal|last1=Dziarski|first1=Roman|last2=Gupta|first2=Dipika|title=The peptidoglycan recognition proteins (PGRPs)|journal=Genome Biology|date=2006|volume=7|issue=8|pages=232|doi=10.1186/gb-2006-7-8-232}} 1 : Peptidoglycan recognition proteins |
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