Perfect Weapon or The Perfect Weapon may refer to:

• The Perfect Weapon (1991 film), starring Jeff Speakman
• The Perfect Weapon (2016 film), starring Steven Seagal
• "Perfect Weapon" (song), a 2010 song by Black Veil Brides
• Perfect Weapon (TV series), a British TV series for National Geographic
• Perfect Weapon (video game), a 1996 video game for Windows and Playstation
• Star Wars: The Perfect Weapon, a 2015 short story in the Journey to Star Wars book series

• Mometasone
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• Mo Minetti
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