词条 | PF-06647020 |
释义 |
Antibody-drug conjugates use a monoclonal antibody that binds to tumors cells linked to a cytotoxic drug. This allows the drug to selectively target the cells that the antibody binds to. PTK7 is expressed by many tumors, including ovarian cancer, breast cancer, and non-small cell lung cancer.[3] Early clinical trial results show a 50% response rate in patients with triple negative breast cancer and an almost complete response in ovarian tumors resistant to platinum-based chemotherapies.[4] References1. ^{{cite web|url=http://adcreview.com/tag/pf-06647020/ |title=PF-06647020 Archives – ADC Review ADC Review |publisher=Adcreview.com |date= |accessdate=2017-05-22}} {{oncology-stub}}2. ^{{cite web|url=http://adcreview.com/pfizer-adc-development-overview-2016/ |title=Pfizer Oncology: ADC Development Overview (2016) – ADC Review ADC Review |publisher=Adcreview.com |date= |accessdate=2017-05-22}} 3. ^http://www.pfizer.com/files/news/esmo/ESMO2016_Oncology_Technologies_Fact_Sheet_ADC.pdf 4. ^{{cite web|last=Patrick |first=Margaret |url=http://marketrealist.com/2016/06/abbvie-expects-ptk7-targeted-drug-enhance-oncology-capabilities/ |title=Why AbbVie Expects PTK7 to Enhance Its Oncology Capabilities |publisher=Market Realist |date=2016-06-28 |accessdate=2017-05-22}} 1 : Experimental cancer drugs |
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