| 词条 | Pharmacology of lead |
| 释义 |
Lead intoxicationSymptoms of lead intoxication include constipation, colic, headache, vomiting, blue lines in the upper lip, jaundice, bilious tinge of the conjunctivae, bile in urine, anemia. Some neurological and muscular symptoms include lead tremor and dropped wrists.[2] Lead acetate which was used as a sweetener, was attributed to be one of the major factors contributing to fall of the Roman Empire (not to be confused with the Holy Roman Empire). Response of frog heart to leadFrog heart which has the inert ability (most of the vertebrate hearts have this ability since it has its own indigenous conduction system ,which is autonomic) to continue beating even in the presence of toxicant such as chloroform, restoration is observed in strophathus, tyramine, strontium chloride, caffeine, diuretine, but one of them failed pituitrin; the most effective restoration is observed with adrenaline. Thus makes it an ideal model to assess the activity of lead on a living tissue. This experiment mainly concentrates on the frog heart being depressed by chloroform, what drugs if any are able to cause more or less restoration of the heart beat in the continued presence of chloroform. The whole experiment is done under continue perfusion of Ringer's fluid.[3] Frog heart contractionThe contracting ability of the frog heart increases when the frog is fasted for a duration or so. Response can also be obtained on a fresh frog.The contractibility is mainly attributed to intracellular calcium signalling.[4] References1. ^{{Cite journal|last=Singh|first=Reena|last2=Gautam|first2=Neetu|last3=Mishra|first3=Anurag|last4=Gupta|first4=Rajiv|date=2011|title=Heavy metals and living systems: An overview|url=http://www.ijp-online.com/text.asp?2011/43/3/246/81505|journal=Indian Journal of Pharmacology|language=en|volume=43|issue=3|pages=246–53|doi=10.4103/0253-7613.81505|issn=0253-7613|pmc=3113373|pmid=21713085}} 2. ^{{Cite journal|date= 23 November 1889|title=Announcement|journal=British Journal of Surgery|volume=78|issue=12|pages=1447|doi=10.1002/bjs.1800781213|issn=0007-1323}} 3. ^{{Cite journal|last=Ransom|first=Fred|date=1920-01-01|title=The Restoration of the Frog's Heart in Chloroform Poisoning|url=http://jpet.aspetjournals.org/content/14/5/367|journal=Journal of Pharmacology and Experimental Therapeutics|language=en|volume=14|issue=5|pages=367–377|issn=0022-3565}} 4. ^{{Cite journal|last=Bagur|first=Rafaela|last2=Hajnóczky|first2=György|date=2017|title=Intracellular Ca 2+ Sensing: Its Role in Calcium Homeostasis and Signaling|journal=Molecular Cell|volume=66|issue=6|pages=780–788|doi=10.1016/j.molcel.2017.05.028|issn=1097-2765|pmc=5657234|pmid=28622523}} Further reading
Database{{Medical resources| ICD10 = | ICD9 = | ICDO = C80 | OMIM = 612740 | DiseasesDB = 7307 | MedlinePlus = 002428 | eMedicineSubj = 10732 | eMedicineTopic = | MeshID = D007854 | GeneReviewsNBK = | GeneReviewsName = | NORD = | GARDNum = 6577 | GARDName = Toxicity | Orphanet = 330015 | AO = | RP = Plumbism | WO = | OrthoInfo = | NCI = }} 1 : Biology and pharmacology of chemical elements |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。