| 释义 |
- Function
- References
- Further reading
{{Orphan|date=July 2018}}{{Infobox_gene}}PIF1 5'-to-3' DNA helicase is a protein that in humans is encoded by the PIF1 gene. [1]FunctionThis gene encodes a DNA-dependent adenosine triphosphate (ATP)-metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents telomere elongation by inhibiting the actions of telomerase. Alternative splicing and the use of alternative start codons results in multiple isoforms that are differentially localized to either the mitochondria or the nucleus. [provided by RefSeq, Nov 2013]. References 1. ^{{cite web| title = Entrez Gene: PIF1 5'-to-3' DNA helicase| url = https://www.ncbi.nlm.nih.gov/gene/80119| accessdate = 2018-05-17}}
Further reading {{refbegin | 30em}}- {{cite journal |vauthors=Zhang DH, Zhou B, Huang Y, Xu LX, Zhou JQ |title=The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity |journal=Nucleic Acids Res. |volume=34 |issue=5 |pages=1393–404 |date=2006 |pmid=16522649 |pmc=1390689 |doi=10.1093/nar/gkl029 |url=}}
- {{cite journal |vauthors=Mateyak MK, Zakian VA |title=Human PIF helicase is cell cycle regulated and associates with telomerase |journal=Cell Cycle |volume=5 |issue=23 |pages=2796–804 |date=December 2006 |pmid=17172855 |doi=10.4161/cc.5.23.3524 |url=}}
- {{cite journal |vauthors=Futami K, Shimamoto A, Furuichi Y |title=Mitochondrial and nuclear localization of human Pif1 helicase |journal=Biol. Pharm. Bull. |volume=30 |issue=9 |pages=1685–92 |date=September 2007 |pmid=17827721 |doi= |url=}}
- {{cite journal |vauthors=Gu Y, Masuda Y, Kamiya K |title=Biochemical analysis of human PIF1 helicase and functions of its N-terminal domain |journal=Nucleic Acids Res. |volume=36 |issue=19 |pages=6295–308 |date=November 2008 |pmid=18835853 |pmc=2577353 |doi=10.1093/nar/gkn609 |url=}}
- {{cite journal |vauthors=George T, Wen Q, Griffiths R, Ganesh A, Meuth M, Sanders CM |title=Human Pif1 helicase unwinds synthetic DNA structures resembling stalled DNA replication forks |journal=Nucleic Acids Res. |volume=37 |issue=19 |pages=6491–502 |date=October 2009 |pmid=19700773 |pmc=2770657 |doi=10.1093/nar/gkp671 |url=}}
- {{cite journal |vauthors=Sanders CM |title=Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity |journal=Biochem. J. |volume=430 |issue=1 |pages=119–28 |date=August 2010 |pmid=20524933 |doi=10.1042/BJ20100612 |url=}}
- {{cite journal |vauthors=Gagou ME, Ganesh A, Thompson R, Phear G, Sanders C, Meuth M |title=Suppression of apoptosis by PIF1 helicase in human tumor cells |journal=Cancer Res. |volume=71 |issue=14 |pages=4998–5008 |date=July 2011 |pmid=21616935 |doi=10.1158/0008-5472.CAN-10-4404 |url=}}
- {{cite journal |vauthors=Chisholm KM, Aubert SD, Freese KP, Zakian VA, King MC, Welcsh PL |title=A genomewide screen for suppressors of Alu-mediated rearrangements reveals a role for PIF1 |journal=PLoS ONE |volume=7 |issue=2 |pages=e30748 |date=2012 |pmid=22347400 |pmc=3276492 |doi=10.1371/journal.pone.0030748 |url=}}
- {{cite journal |vauthors=Ramanagoudr-Bhojappa R, Chib S, Byrd AK, Aarattuthodiyil S, Pandey M, Patel SS, Raney KD |title=Yeast Pif1 helicase exhibits a one-base-pair stepping mechanism for unwinding duplex DNA |journal=J. Biol. Chem. |volume=288 |issue=22 |pages=16185–95 |date=May 2013 |pmid=23596008 |pmc=3668774 |doi=10.1074/jbc.M113.470013 |url=}}
{{refend}}{{NLM content}}{{gene-15-stub}} |