“Alanine—tRNA ligase”的意思、由来-开放百科全书

词条

Alanine—tRNA ligase

释义

See also
Structural studies
References

{{enzyme
| Name = alanine-tRNA ligase
| EC_number = 6.1.1.7
| CAS_number = 9031-71-4
| IUBMB_EC_number = 6/1/1/7
| GO_code = 0004813
| image =
| width =
| caption =
}}

In enzymology, an alanine-tRNA ligase ({{EC number|6.1.1.7}}) is an enzyme that catalyzes the chemical reaction

ATP + L-alanine + tRNAAla AMP + diphosphate + L-alanyl-tRNAAla

The 3 substrates of this enzyme are ATP, L-alanine, and tRNA(Ala), whereas its 3 products are AMP, diphosphate, and L-alanyl-tRNA(Ala).

This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-alanine:tRNAAla ligase (AMP-forming). Other names in common use include alanyl-tRNA synthetase, alanyl-transfer ribonucleate synthetase, alanyl-transfer RNA synthetase, alanyl-transfer ribonucleic acid synthetase, alanine-transfer RNA ligase, alanine transfer RNA synthetase, alanine tRNA synthetase, alanine translase, alanyl-transfer ribonucleate synthase, AlaRS, and Ala-tRNA synthetase. This enzyme participates in alanine and aspartate metabolism and aminoacyl-trna biosynthesis.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1RIQ}}, {{PDB link|1V4P}}, {{PDB link|1YFR}}, {{PDB link|1YFS}}, {{PDB link|1YFT}}, {{PDB link|1YGB}}, and {{PDB link|2E1B}}.

References

{{cite journal |vauthors=HOLLEY RW, GOLDSTEIN J | year = 1959 | title = An alanine-dependent, ribonuclease-inhibited conversion of adenosine 5'-phosphate to adenosine triphosphate. II. Reconstruction of the system from purified components | journal = J. Biol. Chem. | volume = 234 | pages = 1765–8 | pmid = 13672960 | issue = 7 }}
{{cite journal | author = Webster GC | year = 1961 | title = Isolation of an alanine-activating enzyme from pig liver | journal = Biochim. Biophys. Acta | volume = 49 | pages = 141–152 | doi = 10.1016/0006-3002(61)90877-0 | pmid = 13783653 }}

{{Ligases CO CS and CN}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{DEFAULTSORT:Alanine-tRNA ligase}}{{ligase-stub}}

2 : EC 6.1.1|Enzymes of known structure

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See also

Structural studies

References