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词条 Polycomb repressive complex 1
释义

  1. References

Polycomb repressive complex 1 (PRC1) is one of the two classes of Polycomb Repressive complexes, the other being PRC2. Polycomb group proteins play a major role in transcriptional regulation during development. Polycomb Repressive Complexes PRC1 and PRC2 function in the silencing of expression of the Hox gene network involved in development as well as the inactive X chromosome.[1]PRC1 inhibits the activated form of RNA polymerase II preinitiation complex with the use of H3K27me. PRC1 binds to three nucleosomes, this is believed to limit access of chromatin to transcription factors and therefore limit gene expression.[2]

References

1. ^{{Cite journal|last=Plath|first=Kathrin|last2=Fang|first2=Jia|last3=Mlynarczyk-Evans|first3=Susanna K.|last4=Cao|first4=Ru|last5=Worringer|first5=Kathleen A.|last6=Wang|first6=Hengbin|last7=Cruz|first7=Cecile C. de la|last8=Otte|first8=Arie P.|last9=Panning|first9=Barbara|date=2003-04-04|title=Role of Histone H3 Lysine 27 Methylation in X Inactivation|url=http://science.sciencemag.org/content/300/5616/131|journal=Science|language=en|volume=300|issue=5616|pages=131–135|doi=10.1126/science.1084274|issn=0036-8075|pmid=12649488}}
2. ^{{Cite journal|last=Lehmann|first=Lynn|last2=Ferrari|first2=Roberto|last3=Vashisht|first3=Ajay A.|last4=Wohlschlegel|first4=James A.|last5=Kurdistani|first5=Siavash K.|last6=Carey|first6=Michael|date=2012-10-19|title=Polycomb Repressive Complex 1 (PRC1) Disassembles RNA Polymerase II Preinitiation Complexes|url=http://www.jbc.org/content/287/43/35784|journal=Journal of Biological Chemistry|language=en|volume=287|issue=43|pages=35784–35794|doi=10.1074/jbc.M112.397430|issn=0021-9258|pmid=22910904|pmc=3476247}}

1 : Proteins
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