| 词条 | Pregnenolone acetate |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = [(3S,8S,9S,10R,13S,14S,17S)-17-Acetyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate | image = Pregnenolone acetate.svg | width = 250px | tradename = Antofin, Previsone, Pregno-Pan | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = Topical | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 1778-02-5 | CAS_supplemental = | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = 2723722 | IUPHAR_ligand = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 2005918 | UNII = 0G0WWV404B | KEGG = C14658 | ChEBI = 34930 | ChEMBL = | synonyms = Pregn-5-en-3β-ol-20-one 3β-acetate, Antofin, Artivis, Enescorb, Previsone, Sharmone, Pregnenolone-3-acetate, 1778-02-5, 3α-Acetoxy-5-pregnen-20-one, ZINC6304690, NSC 64827, Acetic acid 20-oxopregn-5-en-3alpha-yl ester[1] | C=23 | H=34 | O=3 | SMILES = CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)OC(=O)C)C)C | StdInChI_Ref = | StdInChI = 1S/C23H34O3/c1-14(24)19-7-8-20-18-6-5-16-13-17(26-15(2)25)9-11-22(16,3)21(18)10-12-23(19,20)4/h5,17-21H,6-13H2,1-4H3/t17-,18-,19+,20-,21-,22-,23+/m0/s1 | StdInChIKey_Ref = | StdInChIKey = CRRKVZVYZQXICQ-RJJCNJEVSA-N }}Pregnenolone acetate (brand names Antofin, Previsone, Pregno-Pan), also known as pregn-5-en-3β-ol-20-one 3β-acetate, is a synthetic pregnane steroid and an ester of pregnenolone which is described as a glucocorticoid and as a skin-conditioning and skin anti-aging agent.[2][3] It has been found to significantly reduce wrinkles in elderly women when applied in the form of a 0.5% topical cream, effects which were suggested to be due to improved hydration of the skin.[3] Pregnenolone acetate has been marketed in France in a topical cream containing 1% pregnenolone acetate and 10% "sex hormone" for the treatment of premature skin aging but was withdrawn from the market in 1992.[3] Although the medication has been described by some sources as a glucocorticoid, other authors have stated that systemic pregnenolone acetate has no undesirable metabolic or toxic effects even at high dosages.[4] See also
References1. ^National Center for Biotechnology Information. PubChem Compound Database; CID=11013784, https://pubchem.ncbi.nlm.nih.gov/compound/11013784 (accessed Mar. 10, 2019). {{Other dermatological preparations}}{{Glucocorticoids and antiglucocorticoids}}{{Glucocorticoid receptor modulators}}{{Steroid-stub}}2. ^{{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA665|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=665–}} 3. ^1 2 {{cite book|author=Council of Europe. Committee of Experts on Cosmetic Products|title=Active Ingredients Used in Cosmetics: Safety Survey|url=https://books.google.com/books?id=tWJLUWT06BEC&pg=PA325|year=2008|publisher=Council of Europe|isbn=978-92-871-6298-4|pages=325–}} 4. ^{{cite journal | vauthors = Lamb JH, Kelly FC, Shackelford PO, Rebell G, Koons RC | title = Pregnenolone acetate in treatment of mycetoma (nocardiosis) | journal = AMA Arch Derm Syphilol | volume = 67 | issue = 2 | pages = 141–5 | year = 1953 | pmid = 13029897 | doi = | url = }} 7 : Abandoned drugs|Acetate esters|Steroid esters|Glucocorticoids|Ketones|Pregnanes|Prodrugs |
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