“Albendazole monooxygenase”的意思、由来-开放百科全书

词条

Albendazole monooxygenase

释义

References

{{enzyme
| Name = Albendazole monooxygenase
| EC_number = 1.14.13.32
| CAS_number = 101299-59-6
| IUBMB_EC_number = 1/14/13/32
| GO_code = 0047638
| image =
| width =
| caption =
}}

In enzymology, an albendazole monooxygenase ({{EC number|1.14.13.32}}) is an enzyme that catalyzes the chemical reaction

albendazole + NADPH + H⁺ + O₂ albendazole S-oxide + NADP⁺ + H₂O

The four substrates of this enzyme are albendazole, NADPH, H⁺, and O₂, whereas its three products are albendazole S-oxide, NADP⁺, and H₂O.

This enzyme is coded by the gene for CYP3A4^[1]^[2] and belongs to the family of oxidoreductases, specifically those acting on paired donors, with O₂ as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O₂ with NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor. The systematic name of this enzyme class is albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming). Other names in common use include albendazole oxidase, and albendazole sulfoxidase. It employs one cofactor, FAD.

References

1. ^{{cite web | title=Showing Protein Cytochrome P450 3A4 (HMDBP01018) | work=Human Metabolome Database | accessdate=2017-08-05 | url=http://www.hmdb.ca/proteins/HMDBP01018}}
2. ^Enzyme 1.14.13.32 at KEGG

{{cite journal | vauthors = Fargetton X, Galtier P, Delatour P | date = 1986 | title = Sulfoxidation of albendazole by a cytochrome P450-independent monooxygenase from rat liver microsomes | journal = Vet. Res. Commun. | volume = 10 | pages = 317–324 | pmid = 3739217 | doi = 10.1007/BF02213995 | issue = 4 }}

4 : EC 1.14.13|NADPH-dependent enzymes|Flavin enzymes|Enzymes of unknown structure

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