| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Proprotein convertase subtilisin/kexin type 1 inhibitor is a protein that in humans is encoded by the PCSK1N gene. [1]FunctionThe protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. The proprotein is further processed into multiple short peptides. A polymorphism within this gene may be associated with obesity. References 1. ^{{cite web| title = Entrez Gene: Proprotein convertase subtilisin/kexin type 1 inhibitor| url = https://www.ncbi.nlm.nih.gov/gene/27344| accessdate = 2017-02-28}}
Further reading {{refbegin | 2}}- {{cite journal |vauthors=Fortenberry Y, Hwang JR, Apletalina EV, Lindberg I |title=Functional characterization of ProSAAS: similarities and differences with 7B2 |journal=J. Biol. Chem. |volume=277 |issue=7 |pages=5175–86 |year=2002 |pmid=11719503 |doi=10.1074/jbc.M104531200 |url=}}
- {{cite journal |vauthors=Wada M, Ren CH, Koyama S, Arawaka S, Kawakatsu S, Kimura H, Nagasawa H, Kawanami T, Kurita K, Daimon M, Hirano A, Kato T |title=A human granin-like neuroendocrine peptide precursor (proSAAS) immunoreactivity in tau inclusions of Alzheimer's disease and parkinsonism-dementia complex on Guam |journal=Neurosci. Lett. |volume=356 |issue=1 |pages=49–52 |year=2004 |pmid=14746899 |doi= |url=}}
- {{cite journal |vauthors=Kudo H, Liu J, Jansen EJ, Ozawa A, Panula P, Martens GJ, Lindberg I |title=Identification of proSAAS homologs in lower vertebrates: conservation of hydrophobic helices and convertase-inhibiting sequences |journal=Endocrinology |volume=150 |issue=3 |pages=1393–9 |year=2009 |pmid=18948394 |pmc=2654743 |doi=10.1210/en.2008-1301 |url=}}
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