| 词条 | Propylpyrazoletriol |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = 4-[2,3-bis(4-hydroxyphenyl)-4-propyl-1H-pyrazol-5-ylidene]cyclohexa-2,5-dien-1-one | image = Propylpyrazoletriol.svg | width = | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 263717-53-9 | CAS_supplemental = | ATC_prefix = | ATC_suffix = | PubChem = 6095481 | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 16142497 | C=24 | H=22 | N=2 | O=3 | molecular_weight = 386.44308 g/mol | smiles = CCCC1=C(N(NC1=C2C=CC(=O)C=C2)C3=CC=C(C=C3)O)C4=CC=C(C=C4)O | StdInChI = 1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,25,28-29H,2-3H2,1H3 | StdInChIKey = UOSWGERPQQOSHS-UHFFFAOYSA-N | synonyms = }}Propylpyrazoletriol (PPT) is a synthetic, nonsteroidal agonist of ERα with 400-fold selectivity over ERβ[1] that is used widely in scientific research to study the function of ERα.[2][3][4] Though originally thought to be highly selective for ERα, PPT has subsequently been found to also act as an agonist of the GPER (GPR30).[5] See also
References1. ^{{cite book|author1=Eckhard Ottow|author2=Hilmar Weinmann|title=Nuclear Receptors as Drug Targets|url=https://books.google.com/books?id=iATfLbPgRugC&pg=PA50|date=8 September 2008|publisher=John Wiley & Sons|isbn=978-3-527-62330-3|pages=50–}} {{Estrogenics}}{{pharmacology-stub}}2. ^{{cite book|author1=Tony M. Plant|author2=Anthony J. Zeleznik|title=Knobil and Neill's Physiology of Reproduction: Two-Volume Set|url=https://books.google.com/books?id=I1ACBAAAQBAJ&pg=PA2311|date=15 November 2014|publisher=Academic Press|isbn=978-0-12-397769-4|pages=2311–}} 3. ^{{cite book|title=Cytoplasmic and Nuclear Receptors—Advances in Research and Application: 2012 Edition|url=https://books.google.com/books?id=AH0i2PG-MjsC&pg=PT220|date=26 December 2012|publisher=ScholarlyEditions|isbn=978-1-4649-9741-9|pages=220–}} 4. ^{{cite book|title=Synthesis of Non-steroidal Estrogen Receptor Proteolysis Targeting Chimeric Molecules (PROTACS).|url=https://books.google.com/books?id=A8QIy4avIS0C&pg=PA11|year=2008|publisher=ProQuest|isbn=978-0-549-90990-3|pages=11–}} 5. ^{{cite journal|last1=Prossnitz|first1=Eric R.|last2=Barton|first2=Matthias|title=Estrogen biology: New insights into GPER function and clinical opportunities|journal=Molecular and Cellular Endocrinology|volume=389|issue=1–2|year=2014|pages=71–83|issn=0303-7207|doi=10.1016/j.mce.2014.02.002|pmid=24530924|pmc=4040308}} 4 : Ketones|Phenols|Pyrazoles|Synthetic estrogens |
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