Puccinelli is an Italian surname. Notable people with the surname include:

• Aldo Puccinelli (1920–1994), Italian footballer
• André Puccinelli, Brazilian politician
• Angelo Puccinelli, Italian painter
• Dorothy Wagner Puccinelli (1901–1974), American artist
• George Puccinelli (1907–1956), American baseball player
• Keith Puccinelli (born 1950), American artist
• Luca Puccinelli (born 1973), Italian footballer
• Placido Puccinelli (1609–1685), Italian Christian monk and historian

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