| 词条 | RAD140 |
| 释义 |
| verifiedrevid = | IUPAC_name = 2-chloro-4[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino3-methylbenzonitrile | image = RAD140_structure.png | width = 250px | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 1182367-47-0 | PubChem = 44200882 | ChemSpiderID = 26387625 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 4O87Q44KNC | C=20 | H=16 | Cl=1 | N=5 | O=2 | SMILES = ClC1=C(C#N)C=CC(=C1C)N[C@H]([C@H](C)O)C2=NN=C(O2)C3=CC=C(C=C3)C#N | StdInChI = 1S/C20H16ClN5O2/c1-11-16(8-7-15(10-23)17(11)21)24-18(12(2)27)20-26-25-19(28-20)14-5-3-13(9-22)4-6-14/h3-8,12,18,24,27H,1-2H3/t12-,18+/m0/s1 | StdInChIKey = XMBUPPIEVAFYHO-KPZWWZAWSA-N }}RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer, currently under development by Radius Health, Inc. (RDUS).[1][2][3][4] See also
References1. ^{{cite journal|first1=Anusha|last1=Jayaraman|first2=Amy|last2=Christensen|first3=V. Alexandra|last3=Moser|first4=Rebekah S.|last4=Vest|title=Selective Androgen Receptor Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats|journal=Endocrinology|date=April 2014|issn=0013-7227|pages=1398–1406|volume=155|issue=4|pmid=24428527|pmc=3959610|doi=10.1210/en.2013-1725|first5=Chris P.|last5=Miller|first6=Gary|last6=Hattersley|first7=Christian J.|last7=Pike}} {{Androgen receptor modulators}}{{genito-urinary-drug-stub}}2. ^{{cite journal|first1=D. K.|last1=Hamson|first2=S. R.|last2=Wainwright|first3=J. R.|last3=Taylor|first4=B. A.|last4=Jones|title=Androgens Increase Survival of Adult-Born Neurons in the Dentate Gyrus by an Androgen Receptor-Dependent Mechanism in Male Rats|url=http://press.endocrine.org/doi/full/10.1210/en.2013-1129|journal=Endocrinology|date=September 2013|issn=0013-7227|pages=3294–3304|volume=154|issue=9|doi=10.1210/en.2013-1129|pmid=23782943|first5=N. V.|last5=Watson|first6=L. a. M.|last6=Galea}} 3. ^{{cite journal|first1=Chris P.|last1=Miller|first2=Maysoun|last2=Shomali|first3=C. Richard|last3=Lyttle|first4=Louis St. L.|last4=O’Dea|title=Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140|journal=ACS Medicinal Chemistry Letters|date=February 2011|pages=124–129|volume=2|issue=2|pmid=24900290|pmc=4018048|doi=10.1021/ml1002508|first5=Hillary|last5=Herendeen|first6=Kyla|last6=Gallacher|first7=Dottie|last7=Paquin|first8=Dennis R.|last8=Compton|first9=Bishwabhusan|last9=Sahoo|first10=Sean A.|last10=Kerrigan|first11=Matthew S.|last11=Burge|first12=Michael|last12=Nickels|first13=Jennifer L.|last13=Green|first14=John A.|last14=Katzenellenbogen|first15=Alexei|last15=Tchesnokov|first16=Gary|last16=Hattersley}} 4. ^{{cite book|last1=Chris Miller|last2=Maysoun Shomali|last3=C Richard Lyttle|last4=Gary Hattersley|title=A Selective Androgen Receptor Modulator (RAD140) Induces Inflammation in Rat Right Heart Ventricle: Evidence for an Androgen-Specific, Species-Specific Mechanism|url=http://press.endocrine.org/doi/abs/10.1210/endo-meetings.2012.NRSH.9.SUN-525|publisher=The Endocrine Society|journal=Roles of Androgen & Glucocorticoid Receptors in Physiology & Disease (Translational)|date=24 June 2012|pages=SUN–525-SUN-525|series=Meeting Abstracts|doi=10.1210/endo-meetings.2012.nrsh.9.sun-525}} 4 : Chloroarenes|Designer drugs|Nitriles|Selective androgen receptor modulators |
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