“Rahul Desikan”的意思、由来-开放百科全书

Rahul Desikan is an Indian-American neuroscientist. He is Assistant Professor of Radiology & Biomedical Imaging, Neurology and Pediatrics at UCSF,^[1] and co-director of Laboratory for Precision Neuroimaging.^[2]^[3] Desikan's achievements became publicly known in a Washington Post article detailing his lifelong commitment to preventing and treating Alzheimer's disease and his continuing work as a scientist living with ALS.^[4]^[5] Desikan has been vocal about the need for increased awareness and research funding for ALS, and has voiced his unique perspective as both ALS researcher and ALS patient in op-ed articles appearing in the Washington Post^[6] and the San Francisco Chronicle^[7].

Education and Early Influences

Desikan completed his BA, MD and PhD training at Boston University, Radiology Residency at UCSD and Neuroradiology Fellowship at UCSF. He completed postdoctoral fellowships in Neuroimaging with Bruce Fischl at the Athinoula A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital and Neurogenetics with Anders Dale at UCSD.^[8]

Innovation in the Understanding of Neurodegenerative Disease

Desikan’s work focuses on investigating the pathobiology underlying neurodegenerative and neurodevelopmental disorders.^[9] Using 'big data' acquired through ongoing global collaborations, he has innovated a variety of cross disciplinary methods to identify novel risk factors for brain diseases.^[9]

Significant Scientific Contributions

Desikan’s scientific career has focused on helping to understand and treat neurodegenerative diseases, specifically Alzheimer's disease. His major scientific contributions include:

1) Development of an automated atlas of the human cerebral cortex (Desikan-Killiany Atlas in FreeSurfer),^[10] and its role as a quantitative biomarker for neurodegeneration in Alzheimer's disease.

2) Characterization of the synergistic relationship between amyloid and tau pathology in Alzheimer’s disease.^[11]^[12]

3) Development of the polygenic hazard score (PHS)^[13]^[14] for predicting Alzheimer’s disease age of onset, in collaboration with [https://scholar.google.com/citations?user=Po0VEiYAAAAJ Chun Chieh Fan] and Anders Dale.^[15]^[16]^[17] A commercial version of PHS, which calculates genetic risk for an individual using genomic data from 23andMe and Ancestry.com, is available from Dash Genomics.^[18]

4) Helping develop and validate methods to quantify genetic pleiotropy.^[19] These genetic pleiotropy methods have provided valuable insights across a number of diseases and identified Novel Single Nucleotide Polymorphisms (SNPs) associated with increased risk for schizophrenia, bipolar disorder,^[20] Alzheimer's disease,^[21] Parkinson's disease, frontotemporal dementia,^[22]^[23] corticobasal degeneration,^[24] hypertension, hypercholesterolemia and coronary artery disease.^[25]

ALS Diagnosis

In February 2017, Desikan was diagnosed with amyotrophic lateral sclerosis, one of the very neurodegenerative diseases that has been the focus of his research. His battle with the disease, both personal and scientific,^[26] was featured in The Washington Post,^[4] in a cover story by reporter [https://www.washingtonpost.com/people/laurie-mcginley/ Laurie McGinley]. Unable to speak, walk or use his hands, Desikan continues to pursue research and has published more than 25 papers since his diagnosis.^[27]^[28] His recent work focuses on development of a cardiovascular PHS for Alzheimer's disease and characterizing the genetic architecture of ALS.^[27]^[28] The ALS Association featured his unique story and groundbreaking work in a 2018 article.^[29] Boston University's Bostonia magazine featured Desikan in a 2018 article.^[30] Desikan's story was also featured as a cover story on American Broadcasting Company's Good Morning America on Friday, November 23, 2018.^[31]^[32]

Awards

References

1. ^{{Cite web|url=https://profiles.ucsf.edu/rahul.desikan|title=Rahul Desikan {{!}} UCSF Profiles|website=profiles.ucsf.edu|language=en|access-date=2018-08-03}}
2. ^{{Cite web|url=https://precisionneuro-radiology.ucsf.edu|title=Laboratory for Precision Neuroimaging|last=|first=|date=|website=Laboratory for Precision Neuroimaging at UCSF Department of Radiology and Biomedical Imaging|language=en-US|access-date=2018-10-30}}
3. ^{{Cite news|url=https://radiology.ucsf.edu/research/research-interest-groups/neuroimaging|title=Neuroimaging RIG|date=2017-05-08|work=UCSF Radiology|access-date=2018-08-03|language=en}}
4. ^¹{{cite web|url=https://www.washingtonpost.com/news/national/wp/2018/06/13/feature/devastated-by-als-trying-to-save-others/|title=Devastated by ALS, trying to save others|last=McGinley|first=Laurie|date=|website=Washington Post|access-date=}}
5. ^{{Cite web|url=https://www.bu.edu/bostonia/rahul-desikan-als-research/|title=Rahul Desikan's Quest to Find Out What Causes ALS {{!}} Bostonia {{!}} BU Alumni Magazine|website=www.bu.edu|access-date=2018-11-09}}
6. ^{{cite web|url=https://www.washingtonpost.com/national/health-science/im-a-scientist-studying-brain-illnesses-now-im-a-lock-in-living-with-one-of-them-lou-gehrigs-disease/2019/03/01/32a31100-3625-11e9-af5b-b51b7ff322e9_story.html?noredirect=on&utm_term=.2a4852932d96/|title=I'm a scientist studying brain illnesses. Now I'm a lock-in, living with one of them: Lou Gehrig's disease.|last=Desikan|first=Rahul|date=|website=Washington Post|access-date=}}
7. ^{{cite web|url=https://www.sfchronicle.com/opinion/article/Genetic-research-may-hold-promise-for-ALS-13654068.php?utm_campaign=CMS%20Sharing%20Tools%20(Premium)|title=Genetic research may hold promise for ALS, Alzheimer's|last=Desikan|first=Rahul|date=|website=SF Chronicle|access-date=}}
8. ^{{Cite journal|date=2006-07-01|title=An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest|url=https://www.sciencedirect.com/science/article/pii/S1053811906000437|journal=NeuroImage|language=en|volume=31|issue=3|pages=968–980|doi=10.1016/j.neuroimage.2006.01.021|pmid=16530430|issn=1053-8119|last1=Desikan|first1=Rahul S.|last2=Ségonne|first2=Florent|last3=Fischl|first3=Bruce|last4=Quinn|first4=Brian T.|last5=Dickerson|first5=Bradford C.|last6=Blacker|first6=Deborah|last7=Buckner|first7=Randy L.|last8=Dale|first8=Anders M.|last9=Maguire|first9=R. Paul|last10=Hyman|first10=Bradley T.|last11=Albert|first11=Marilyn S.|last12=Killiany|first12=Ronald J.}}
9. ^¹{{Cite web|url=https://www.ucsf.edu/news/2018/04/410181/ucsf-researcher-identifies-risk-genes-als|title=UCSF Researcher Identifies Risk Genes for ALS|website=UC San Francisco|language=en|access-date=2018-08-03}}
10. ^{{cite journal |doi=10.1016/S0896-6273(02)00569-X |pmid=11832223 |title=Whole Brain Segmentation |journal=Neuron |volume=33 |issue=3 |pages=341–55 |year=2002 |last1=Fischl |first1=Bruce |last2=Salat |first2=David H. |last3=Busa |first3=Evelina |last4=Albert |first4=Marilyn |last5=Dieterich |first5=Megan |last6=Haselgrove |first6=Christian |last7=Van Der Kouwe |first7=Andre |last8=Killiany |first8=Ron |last9=Kennedy |first9=David |last10=Klaveness |first10=Shuna |last11=Montillo |first11= Albert |last12=Makris |first12=Nikos |last13=Rosen |first13=Bruce |last14=Dale |first14=Anders M. }}
11. ^{{Cite news|url=https://www.sciencedaily.com/releases/2015/02/150217131120.htm|title=Tau-associated MAPT gene increases risk for Alzheimer's disease|work=ScienceDaily|access-date=2018-08-03|language=en}}
12. ^{{cite journal |doi=10.1001/archneurol.2011.3354 |pmid=22529247 |pmc=3423526 |title=Amyloid-β – associated clinical decline occurs only in the presence of elevated P-tau |journal=Archives of Neurology |volume=69 |issue=6 |pages=709–13 |year=2012 |last1=Desikan |first1=Rahul S. |last2=McEvoy |first2=Linda K. |last3=Thompson |first3=Wesley K. |last4=Holland |first4=Dominic |last5=Brewer |first5=James B. |last6=Aisen |first6=Paul S. |last7=Sperling |first7=Reisa A. |last8=Dale |first8=Anders M. |collaboration=Alzheimer's Disease Neuroimaging Initiative |display-authors=3 }}
13. ^{{Cite news|url=https://www.theguardian.com/society/2017/mar/22/new-alzheimers-test-can-predict-age-when-disease-will-appear|title=New Alzheimer's test can predict age when disease will appear|work=TheGuardian|access-date=2017-03-22|language=en}}
14. ^{{Cite news|url=https://www.hindustantimes.com/health-and-fitness/soon-a-gene-test-may-predict-the-age-at-which-you-may-be-at-risk-of-alzheimer-s/story-Pd2xqUYO9kaiIUdaMwZ1UK.html|title=Soon a gene test may predict the age at which you may be at risk of Alzheimer’s|work=HindustanTimes|access-date=2017-03-22|language=en}}
15. ^{{cite journal |doi=10.1371/journal.pmed.1002258 |pmid=28323831 |pmc=5360219 |title=Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score |journal=PLOS Medicine |volume=14 |issue=3 |pages=e1002258 |year=2017 |last1=Desikan |first1=Rahul S. |last2=Fan |first2=Chun Chieh |last3=Wang |first3=Yunpeng |last4=Schork |first4=Andrew J. |last5=Cabral |first5=Howard J. |last6=Cupples |first6=L. Adrienne |last7=Thompson |first7=Wesley K. |last8=Besser |first8=Lilah |last9=Kukull |first9=Walter A. |last10=Holland |first10=Dominic |last11=Chen |first11=Chi-Hua |last12=Brewer |first12=James B. |last13=Karow |first13=David S. |last14=Kauppi |first14=Karolina |last15=Witoelar |first15=Aree |last16=Karch |first16=Celeste M. |last17=Bonham |first17=Luke W. |last18=Yokoyama |first18=Jennifer S. |last19=Rosen |first19=Howard J. |last20=Miller |first20=Bruce L. |last21=Dillon |first21=William P. |last22=Wilson |first22=David M. |last23=Hess |first23=Christopher P. |last24=Pericak-Vance |first24=Margaret |last25=Haines |first25=Jonathan L. |last26=Farrer |first26=Lindsay A. |last27=Mayeux |first27=Richard |last28=Hardy |first28=John |last29=Goate |first29=Alison M. |last30=Hyman |first30=Bradley T. |last31=Schellenberg |first31=Gerard D. |last32=McEvoy |first32=Linda K. |last33=Andreassen |first33=Ole A. |last34=Dale |first34=Anders M. |display-authors=29 }}
16. ^{{cite web| title =New Test Helps People Predict When They May Get Alzheimer's Disease| website =The Independent| url =https://www.independent.co.uk/life-style/health-and-families/health-news/alzheimers-signs-dementia-new-genetic-test-predicts-risk-plos-medicine-university-california-a7642156.html}}
17. ^{{Cite journal|last=Salat|first=D. H.|date=2004-03-28|title=Thinning of the Cerebral Cortex in Aging|url=https://academic.oup.com/cercor/article/14/7/721/375858|journal=Cerebral Cortex|language=en|volume=14|issue=7|pages=721–730|doi=10.1093/cercor/bhh032|pmid=15054051|issn=1460-2199}}
18. ^{{Cite web |url=https://www.dashgenomics.com/ |title=Personalized Alzheimer's disease risk from your genomic data |website=Dash Genomics |language=en |access-date=2018-08-05}}
19. ^{{cite journal|author1=Andreassen|first1=O. A.|last2=Djurovic|first2=S|last3=Thompson|first3=W. K.|last4=Schork|first4=A. J.|last5=Kendler|first5=K. S. |last6=O'Donovan|first6=M. C.|last7=Rujescu|first7=D|last8=Werge|first8=T|last9=Van De Bunt|first9=M|year=2013|title=Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with Cardiovascular disease{{!}}cardiovascular-disease risk factors|url=|journal=The American Journal of Human Genetics|volume=92|issue=2|pages=197–209 |doi=10.1016/j.ajhg.2013.01.001 |pmc=3567279 |pmid=23375658 |via= |last10=Morris|first10=A. P.|last11=McCarthy|first11=M. I.|author12=International Consortium for Blood Pressure GWAS |author13=Diabetes Genetics Replication Meta-analysis Consortium |author14=Psychiatric Genomics Consortium Schizophrenia Working Group |last15=Roddey|first15=J. C.|last16=McEvoy|first16=L. K.|last17=Desikan|first17=R. S.|last18=Dale|first18=A. M.}}
20. ^{{cite journal |doi=10.1371/journal.pgen.1003455 |pmid=23637625 |title=Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate |journal=PLoS Genetics |volume=9 |issue=4 |pages=e1003455 |year=2013 |last1=Andreassen |first1=Ole A. |last2=Thompson |first2=Wesley K. |last3=Schork |first3=Andrew J. |last4=Ripke |first4=Stephan |last5=Mattingsdal |first5=Morten |last6=Kelsoe |first6=John R. |last7=Kendler |first7=Kenneth S. |last8=O'Donovan |first8=Michael C. |last9=Rujescu |first9=Dan |last10=Werge |first10=Thomas |last11=Sklar |first11=Pamela |last12=Roddey |first12=J. Cooper |last13=Chen |first13=Chi-Hua |last14=McEvoy |first14=Linda |last15=Desikan |first15=Rahul S. |last16=Djurovic |first16=Srdjan |last17=Dale |first17=Anders M. |pmc=3636100}}
21. ^{{cite journal |doi=10.1161/CIRCULATIONAHA.115.015489 |pmid=25862742 |pmc=4677995 |title=Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease |journal=Circulation |volume=131 |issue=23 |pages=2061–2069 |year=2015 |last1=Desikan |first1=R. S. |last2=Schork |first2=A. J. |last3=Wang |first3=Y. |last4=Thompson |first4=W. K. |last5=Dehghan |first5=A. |last6=Ridker |first6=P. M. |last7=Chasman |first7=D. I. |last8=McEvoy |first8=L. K. |last9=Holland |first9=D. |last10=Chen |first10=C.-H. |last11=Karow |first11=D. S. |last12=Brewer |first12=J. B. |last13=Hess |first13=C. P. |last14=Williams |first14=J. |last15=Sims |first15=R. |last16=O'Donovan |first16=M. C. |last17=Choi |first17=S. H. |last18=Bis |first18=J. C. |last19=Ikram |first19=M. A. |last20=Gudnason |first20=V. |last21=Destefano |first21=A. L. |last22=Van Der Lee |first22=S. J. |last23=Psaty |first23=B. M. |last24=Van Duijn |first24=C. M. |last25=Launer |first25=L. |last26=Seshadri |first26=S. |last27=Pericak-Vance |first27=M. A. |last28=Mayeux |first28=R. |last29=Haines |first29=J. L. |display-authors=etal }}
22. ^{{cite journal |doi=10.1136/jnnp-2016-314411 |pmid=27899424 |pmc=5237405 |title=Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases |journal=Journal of Neurology, Neurosurgery & Psychiatry |volume=88 |issue=2 |pages=152–164 |year=2017 |last1=Ferrari |first1=Raffaele |last2=Wang |first2=Yunpeng |last3=Vandrovcova |first3=Jana |last4=Guelfi |first4=Sebastian |last5=Witeolar |first5=Aree |last6=Karch |first6=Celeste M |last7=Schork |first7=Andrew J |last8=Fan |first8=Chun C |last9=Brewer |first9=James B |last10=Momeni |first10=Parastoo |last11=Schellenberg |first11=Gerard D |last12=Dillon |first12=William P |last13=Sugrue |first13=Leo P |last14=Hess |first14=Christopher P |last15=Yokoyama |first15=Jennifer S |last16=Bonham |first16=Luke W |last17=Rabinovici |first17=Gil D |last18=Miller |first18=Bruce L |last19=Andreassen |first19=Ole A |last20=Dale |first20=Anders M |last21=Hardy |first21=John |last22=Desikan |first22=Rahul S }}
23. ^{{Cite news|url=https://radiology.ucsf.edu/blog/establishing-link-between-frontotemporal-dementia-ftd-and-immune-dysfunction|title=Establishing a Link Between Frontotemporal Dementia (FTD) and Immune Dysfunction|date=2018-01-11|work=UCSF Radiology|access-date=2018-08-05|language=en}}
24. ^{{cite journal |doi=10.1007/s00401-017-1693-y |pmid=28271184 |pmc=5429027 |title=Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia |journal=Acta Neuropathologica |volume=133 |issue=5 |pages=825–837 |year=2017 |last1=Yokoyama |first1=Jennifer S. |last2=Karch |first2=Celeste M. |last3=Fan |first3=Chun C. |last4=Bonham |first4=Luke W. |last5=Kouri |first5=Naomi |last6=Ross |first6=Owen A. |last7=Rademakers |first7=Rosa |last8=Kim |first8=Jungsu |last9=Wang |first9=Yunpeng |last10=Höglinger |first10=Günter U. |last11=Müller |first11=Ulrich |last12=Ferrari |first12=Raffaele |last13=Hardy |first13=John |last14=Momeni |first14=Parastoo |last15=Sugrue |first15=Leo P. |last16=Hess |first16=Christopher P. |last17=James Barkovich |first17=A. |last18=Boxer |first18=Adam L. |last19=Seeley |first19=William W. |last20=Rabinovici |first20=Gil D. |last21=Rosen |first21=Howard J. |last22=Miller |first22=Bruce L. |last23=Schmansky |first23=Nicholas J. |last24=Fischl |first24=Bruce |last25=Hyman |first25=Bradley T. |last26=Dickson |first26=Dennis W. |last27=Schellenberg |first27=Gerard D. |last28=Andreassen |first28=Ole A. |last29=Dale |first29=Anders M. |last30=Desikan |first30=Rahul S. }}
25. ^{{cite journal |doi=10.1161/CIRCRESAHA.115.306629 |pmid=26487741 |title=Identifying Novel Gene Variants in Coronary Artery Disease and Shared Genes with Several Cardiovascular Risk Factors Novelty and Significance |journal=Circulation Research |volume=118 |issue=1 |pages=83–94 |year=2016 |last1=Leblanc |first1=Marissa |last2=Zuber |first2=Verena |last3=Andreassen |first3=Bettina Kulle |last4=Witoelar |first4=Aree |last5=Zeng |first5=Lingyao |last6=Bettella |first6=Francesco |last7=Wang |first7=Yunpeng |last8=McEvoy |first8=Linda K. |last9=Thompson |first9=Wesley K. |last10=Schork |first10=Andrew J. |last11=Reppe |first11=Sjur |last12=Barrett-Connor |first12=Elizabeth |last13=Ligthart |first13=Symen |last14=Dehghan |first14=Abbas |last15=Gautvik |first15=Kaare M. |last16=Nelson |first16=Christopher P. |last17=Schunkert |first17=Heribert |last18=Samani |first18=Nilesh J. |last19=Ridker |first19=Paul M |last20=Chasman |first20=Daniel I. |last21=Aukrust |first21=Pål |last22=Djurovic |first22=Srdjan |last23=Frigessi |first23=Arnoldo |last24=Desikan |first24=Rahul S. |last25=Dale |first25=Anders M. |last26=Andreassen |first26=Ole A. |last27=Andreassen |first27=O. A. |pmc=5609485}}
26. ^{{cite web| title =New Study Reveals Two Genes Associated with High Risk for ALS| website =ALS News Today| url =https://alsnewstoday.com/2018/04/13/als-study-reveals-two-genes-associated-with-high-risk-for-disease/}}
27. ^¹{{Citation|last=Desikan|first=Vasudha|title=Rahul UCSF Talk|date=2018-06-10|url=https://vimeo.com/274386064|access-date=2018-08-05}}
28. ^¹{{Cite web|url=https://scholar.google.com/citations?hl=en&user=tC20o3UAAAAJ|title=Rahul Desikan - Google Scholar Citations|website=scholar.google.com|access-date=2018-08-06}}
29. ^{{cite web|url=https://alsadotorg.wordpress.com/2018/08/10/als-researcher-living-with-als-continues-to-work-toward-a-cure/|title=ALS Researcher Living With ALS Continues to Work Toward a Cure|last=|first=|date=|website=ALS Association|access-date=}}
30. ^{{cite web|url=https://www.bu.edu/bostonia/rahul-desikan-als-research/|title=Rahul Desikan's story of love, science and facing down death|last=|first=|date=|website=bu|access-date=}}
31. ^{{cite web|url=https://www.goodmorningamerica.com/wellness/story/scientist-races-find-cure-als-battling-disease-59373042|title=ALS researcher living with the disease still fighting for a cure|last=|first=|date=|website=abcnews|access-date=}}
32. ^{{Cite news|url=https://www.goodmorningamerica.com/wellness/story/scientist-races-find-cure-als-battling-disease-59373042|title=Scientist races to find a cure for ALS while battling the disease himself|last=America|first=Good Morning|work=Good Morning America|access-date=2018-11-23|language=en}}
33. ^{{cite web| title =Cornelius G Dyke Memorial Award| website =ASNR| url =https://www.asnr.org/asnr/about-us/cornelius-g-dyke-award-recipients/}}
34. ^{{cite web| title =Boerger Research Fund| website =ASNR| url =https://foundation.asnr.org/page/grant-recipients/2016-alzheimers-imaging-research-program-grant-recipients/}}
35. ^{{cite web| title =Junior Investigator Award| website =NACC| url =https://www.alz.washington.edu/NONMEMBER/GRANTS/sponji.html}}
36. ^{{cite web| title =Outstanding Fellow/Clinical Instructor Award| website =UCSF| url =https://radiology.ucsf.edu/news/honors-awards}}
37. ^{{Cite news|url=https://foundation.asnr.org/page/grant-recipients/|title=Grant Recipients|date=2017-02-11|work=The Foundation of the ASNR|access-date=2018-10-30|language=en-US}}