“Alclometasone”的意思、由来-开放百科全书

词条

Alclometasone

释义

Pharmacology
Indications
Contraindications
Side effects
How supplied
References

{{refimprove|date=November 2018}}{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 477316653
| IUPAC_name = (7R,8S,9S,10R,11S,13S,14S,16R,17R)-7-Chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
| image = Alclometasone.svg
| tradename = Aclovate
| Drugs.com = {{drugs.com|monograph|aclovate}}
| MedlinePlus = a604021
| pregnancy_US = C
| legal_US = Rx only
| routes_of_administration = Topical
| bioavailability = 3% systemically (topical)
| metabolism = Hepatic
| onset = Eczema: 5.3 - 13.9 days; Psoriasis: 6.7 - 14.8 days^[1]
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 66734-13-2
| ATC_prefix = D07
| ATC_suffix = AB10
| ATC_supplemental = {{ATC|S01|BA10}}
| PubChem = 5311000
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00240
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4470541
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 136H45TB7B
| KEGG_Ref =
| KEGG =
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 53776
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1201361
| C=22 | H=29 | Cl=1 | O=5
| smiles = C[C@@H]1C[C@H]2[C@@H]3[C@@H](CC4=CC(=O)C=C[C@@]4([C@H]3[C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)C)Cl
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI =1S/C22H29ClO5/c1-11-6-14-18-15(23)8-12-7-13(25)4-5-20(12,2)19(18)16(26)9-21(14,3)22(11,28)17(27)10-24/h4-5,7,11,14-16,18-19,24,26,28H,6,8-10H2,1-3H3/t11-,14+,15-,16+,18-,19+,20+,21+,22+/m1/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = FJXOGVLKCZQRDN-PHCHRAKRSA-N
}}Alclometasone is a synthetic corticosteroid for topical dermatologic use, possessing anti-inflammatory, antipruritic, and vasoconstrictive properties.^[2]

The prodrug alclometasone dipropionate was originally marketed under the brand name Aclovate by GlaxoSmithKline as a topical cream and ointment. However, generic versions of the drug are available.

Pharmacology

Alclometasone induces the production of lipocortins, formally known as annexins, which inhibit phospholipase A2 – the enzyme responsible for the synthesis of arachidonic acid. Without the oxidation of arachidonic acid, eicosanoids, such as prostaglandins, thromboxanes, and leukotrienes, can't be produced.

Alclometasone also inhibits the release of pro-inflammatory mediators from leukocytes (e.g., cytokines, histamine, leukotrienes, serotonin).

Indications

Alclometasone cream and ointment are indicated for the relief of corticosteroid-responsive dermatoses, including:

atopic dermatitis
eczema
psoriasis
allergic dermatitis
contact dermatitis
actinic dermatitis
kiss-type allergy
skin itch

Alclometasone may be used on sensitive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients.

Contraindications

hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms
cutaneous tuberculosis
chicken pox
perioral dermatitis
acne
rosacea
open wounds
trophic ulcers
viral infection of skin
skin manifestations of syphilis

Side effects

Adverse reactions (sometimes, less than 1-2% cases) include:

burning
itching
erythema
skin reddening
xerodermia
skin irritation
acne
hypopigmentation
prickly heat
folliculitis
white atrophy
hypertrichosis
reinfection of skin

How supplied

Alclometasone as Aclovate is supplied in:

Cream; Topical; 0.05%
Ointment; Topical; 0.05%

References

1. ^{{cite web|url=https://www.drugs.com/ppa/alclometasone.html|title=Alclometasone - Professional Patient Advice|website=Drugs.com|access-date=29 December 2017}}
2. ^{{cite web|url=https://www.drugs.com/pro/alclometasone.html|title=Alclometasone - FDA Prescribing Information|website=Drugs.com|access-date=29 December 2017}}

2 : Glucocorticoids|Organochlorides

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