| 释义 |
- Biography
- Awards and honors
- Selected publications
- References
{{Infobox scientist
| honorific_prefix =
| name = Randal J. Kaufman
| honorific_suffix = Ph.D.
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| alt = Randal Kaufman, Ph.D. in his lab
| caption = Randal J. Kaufman, Ph.D.
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| birth_place = Denver, CO
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| nationality = US
| fields = Hemophilia, metabolic disease, diabetes, inflammation, cancer, neurodegenerationCellular and Molecular Biology
| workplaces = Genetics Institute Inc., Cambridge MAHoward Hughes Medical Institute, Ann Arbor MI University of Michigan Medical Center, Ann Arbor MI Sanford Burnham Prebys Medical Discovery Institute (SBP), La Jolla CA
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| alma_mater = University of Colorado, Boulder
| thesis_title = Development and Maintenance of Drugs Resistance in Cultured Mammalian Cells
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| doctoral_advisor = Robert Schimke, Stanford University, Palo Alto CA
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| notable_students = Andrew Chuan Liu, Xiahua Shen, Jun Wu
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}}Randal J. Kaufman is the director and a professor of the Degenerative Diseases Program, Neuroscience and Aging Center at Sanford Burnham Prebys Medical Discovery Institute (SBP) and an adjunct professor in the Department of Pharmacology at the UC San Diego School of Medicine. Biography Kaufman received his BA at the University of Colorado and went on to obtain his Ph.D. in pharmacology at Stanford University and undertook postdoctoral studies at the Center for Cancer Research at M.I.T., where he was a Helen Hay Whitney postdoctoral fellow with Nobel laureate Phillip Allen Sharp.[1] From 1994-2011, Kaufman was Professor of Biological Chemistry and Internal Medicine, Endowed Chair of Medicine and Investigator of Howard Hughes Medical Research Institute at the University of Michigan Medical School. He joined SBP in 2011.[1] Awards and honors - 1993: Dr. Murray Thelin Award, National Hemophilia Foundation
- 1998: International Association Francaise Des Hemophiles Award, "Prix Henri Chaigneau"
- 1999: Investigator Recognition Award, Intl. Soc. Thrombosis & Haemostasis (ISTH)
- 2000: Distinguished Investigator Award-MI Hemophilia Society
- 2003: Van Wezel Prize, European Society of Animal Cell Technology (ESACT)
- 2006: Fellow of the American Association for the Advancement of Science[2]
- 2007-2017: NIH NIDDK MERIT Award
- 2014, 2015: Thomson Reuters World’s Most Influential Scientific Minds in Biochemistry & Biology[3]
- 2015: Society for Free Radical Research (SFRR), Clinical Science Award
- 2016: Endowed Chair in Cell Biology. SBP Medical Discovery Institute[1]
Selected publications Below is a list of selectecd publications.[4] - Toole JJ, Knopf JL, Wozney JM, Sultzman LA, Buecker RL, Pittman DD, Kaufman RJ, et al. (1984) "Molecular cloning of a cDNA encoding human antihemophilic factor". Nature 312: 342-347.
- Toole JJ, Pittman DD, Orr EC, Murtha P, Wasley LC, Kaufman RJ. (1986) "A large region (~95 kDA) of human factor VIII is dispensable for in vitro procoagulant activity". Proc Natl Acad Sci USA. 83(16):5939-5942. {{PMC|386412}}.
- Dorner AJ, Wasley LC, Kaufman RJ. (1989) "Increased synthesis of secreted proteins induces expression of glucose-regulated proteins in Chinese hamster ovary cells". J Biological Chemistry 264(34):20602-20607. {{PMID|2511206}}.
- Dorner AJ, Wasley LC, Kaufman RJ. (1990) "Protein dissociation from GRP78 and secretion is blocked by depletion of cellular ATP levels". Proc Natl Acad Sci USA. 87:7429-7432. {{PMC|54760}}.
- Nichols WC, Seligsohn U, Zivelin A, Terry VH, Hertel CE, Wheatley MA, Moussalli M, Hauri H-P, Ciavarella N, Kaufman RJ, Ginsburg D. (1998) "Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII". Cell 93:61-70.
- Tirasophon W, Welihinda AA, Kaufman RJ. (1998) "A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells". Genes Dev. 12:1812-1824. {{PMC|316900}}.
- Tirasophon W, Lee K, Callaghan B, Welihinda A, Kaufman RJ. (2000) "The endoribonuclease activity of mammalian Ire1p autoregulates its mRNA and is required for the UPR". Genes Dev. 14: 2725-2736. {{PMC|317029}}.
- Shen X, Ellis RE, Lee K, Liu C, Yang K, Solomon A, Yoshida H, Morimoto R, Kurnit D, Mori K, Kaufman RJ. (2001) "Complementary signaling pathways regulate the UPR and are required for C. elegans development". Cell 107(7):893-903. {{PMID|11779465}}
- Scheuner D, Song B, McEwen E, Liu C, Laybutt R, Gillespie P, Saunders T, Bonner-Weir S., S, Kaufman RJ. (2001) "Translational control is required for the unfolded protein response and in vivo glucose homeostasis". Molecular Cell 7(6):1165-1176. {{PMID|11430820}}
- Lee K, Tirasophon W, Shen X, Michalak M, Prywes R, Okada T, Yoshida H, Mori K, Kaufman RJ. (2002) "IRE1-mediated nonconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response". Genes & Development 16:452-466. {{PMC|155339}}.
- Zhang K, Shen X, Wu J, Sakaki K, Saunders T, Rutkowski TD, Back SH, Kaufman RJ. (2006) "Endoplasmic reticulum stress activates cleavage of CREBH to induce the acute phase response". Cell 124(3):587-599.
- Rutkowski DT, Arnold SM, Miller CN, Wu J, Li J, Gunnison KM, Mori K, Sadighi Akha AA, Raden D, Kaufman RJ. (2006) "Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins". PLoS Biol. 4(11): e374. {{PMC|1634883}}
- Wu J, Rutkowski DT, Dubois M, Swathirajan J, Saunders T, Wang J, Song B, Yau GD-Y, Kaufman RJ. (2007) "ATF6 alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress". Developmental Cell 13(3):351-64. {{PMID|17765679}}.
- Rutkowski DT, Wu J, Back S-H, Callaghan MU, Ferris SP, Iqbal J, Clark R, Miao H, Hassler JR, Fornek J, Katze MG, Hussain MM, Song B, Swathirajan J, Wang J, Yau GD, Kaufman RJ. (2008) "UPR pathways combine to prevent dysregulation of lipid metabolism caused by suppression of transcriptional master regulators". Developmental Cell 15(6):829-840. {{PMC|2923556}}.
- Song B, Scheuner D, Ron D, Pennathur S, Kaufman RJ. (2008) "Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes". J Clinical Investigation 118(10):3378-3389.
- Malhotra JD, Miao. H, Zhang K, Wolfson A, Pennathur S, Pipe SW, Kaufman RJ. (2008) "Antioxidants reduce endoplasmic reticulum stress and improve protein secretion". Proc Natl Acad Sci USA. 105(47): 18525-18530. {{PMC|2587584}}.
- Back SH, Scheuner D, Han J, Song B, Ribick M, Wang J, Gildersleeve RD, Pennathur S, Kaufman RJ. (2009) "Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells". Cell Metabolism 10(1):13-26. {{PMC|2742645}}
- Han J, Back S-H, Hur J, Lin Y-H, Gildersleeve R, Shan J, Yuan CL, Krokowski D, Wang S., Hatzoglou M, Kilberg MS, Sartor MA, Kaufman RJ. (2013) "Endoplasmic reticulum (ER) stress-induced transcriptional regulation increases protein synthesis leading to cell death". Nature Cell Biology 15(5):481-90.
- Hassler JH, Scheuner DL, Wang S, Han JS, Kodali VK, Li P, Nguyen J, George, S, Davis C, Wu, SP, Sartor M, Bai Y, Cavalcoli J, Malhi H, Baudouin G, Zhang Y, Yates 3rd JR, Itkin-Ansari P, Volkmann N, Kaufman RJ. (2015) "The IRE1alpha/XBP1s pathway is essential for the glucose response and protection of beta cells". PLOS Biol. 13(10):e1002277. {{PMC|4607427}}.
- Wang M, Kaufman RJ. (2016) "Protein misfolding in the ER as a conduit to human disease". Nature 529(7586):326-35.
References 1. ^1 2 {{cite web|url=https://www.sbpdiscovery.org/team/randal-kaufman-phd|title=Randal Kaufman, Ph.D. - SBP|website=www.sbpdiscovery.org}}
2. ^{{cite journal|url=http://science.sciencemag.org/content/sci/314/5803/1256.full.pdf |title=AAAS News and Notes |journal=Science |volume=314 |issue=5803 |year=2006 |pages=1256–1260 |doi=10.1126/science.314.5803.1256}}
3. ^{{cite news|last=Robbins |first=Gary |date=13 July 2014 |newspaper=San Diego Union Tribune |url=http://www.sandiegouniontribune.com/news/science/sdut-thomson-reuters-science-2014jul13-htmlstory.html |title=SD home to 48 of world's top scientists}}
- {{cite web|title=The World's Most Influential Scientific Minds 2015 |website=Thomson Reuters |year=2015 |url=http://images.info.science.thomsonreuters.biz/Web/ThomsonReutersScience/%7B37a987a9-e378-4888-8baa-d4ba20efdbfd%7D_tr_scientific_minds_online_final.pdf}}
4. ^{{cite web|url=https://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&term=Kaufman+RJ|title=Kaufman RJ - PubMed - NCBI|last=pubmeddev|website=www.ncbi.nlm.nih.gov}}
{{Authority control}}{{DEFAULTSORT:Kaufman, Randal J.}} 5 : Living people|Stanford University faculty|University of California, San Diego faculty|University of Colorado Boulder alumni|Year of birth missing (living people) |