| 词条 | RB-120 |
| 释义 |
| IUPAC_name = N(S)-2-benzyl-3[(S)-(2-amino-4-methylthio)butyldithio]-1-oxopropyll-alanine benzyl ester | image = RB120 Mesylate.png | width = 260 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_UK = | legal_status = | routes_of_administration = | addiction_liability = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = | ATC_prefix = | ATC_suffix = | PubChem = 54470354 | ChemSpiderID = | C=25 | H=34 | N=2 | O=3 | S=3 | melting_point = | smiles = C[C@@H](C(=O)OCC1=CC=CC=C1)NC(=O)[C@H](CC2=CC=CC=C2)CSSC[C@H](CCSC)N | StdInChI= 1S/C25H34N2O3S3/c1-19(25(29)30-16-21-11-7-4-8-12-21)27-24(28)22(15-20-9-5-3-6-10-20)17-32-33-18-23(26)13-14-31-2/h3-12,19,22-23H,13-18,26H2,1-2H3,(H,27,28)/t19-,22+,23-/m0/s1 | StdInChIKey = XHWYFTNNIZGHRW-PMOQBDJRSA-N }}RB-120 (benzyl (2S)-2-{[(2S)-2-({[(2S)-2-amino-4-methylsulfanylbutyl]disulfanyl}methyl)-3-phenylpropanoyl]amino}propanoate) is an orally active analog of the drug RB-101.[1] It acts as an enkephalinase inhibitor, which is used in scientific research. Via intravenous administration, it is approximately three times as potent as RB-101 or twice as potent as the isolated (S,S) isomer of RB101. However, via i.p. administration it is approximately twice as potent as racemic RB-101 and about as potent as the isolated (S,S) isomer of RB101. During i.v. admistration RB120 is approximately twice as weak as morphine in terms of analgesia, however it is 16x weaker during i.p. and p.o. administration.[1] References1. ^1 {{cite journal |doi=10.1016/S0304-3959(97)00125-5 |title=Pain-suppressive effects on various nociceptive stimuli (thermal, chemical, electrical and inflammatory) of the first orally active enkephalin-metabolizing enzyme inhibitor RB 120 |journal=Pain |volume=73 |issue=3 |pages=383–391 |year=1997 |last1=Noble |first1=Florence |last2=Smadja |first2=Claire |last3=Valverde |first3=Olga |last4=Maldonado |first4=Rafaël |last5=Coric |first5=Pascale |last6=Turcaud |first6=Serge |last7=Fournié-Zaluski |first7=Marie-Claude |last8=Roques |first8=Bernard P. }} {{Opioidergics}}{{Drug-stub}} 1 : Enkephalinase inhibitors |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。