| 词条 | Rob Klose |
| 释义 |
| name = Rob Klose |image = File:Rob Klose photo.jpg | caption = Rob Klose | birth_name = | birth_date = {{birth date and age|1977|12|28}} |alma_mater = {{Plainlist|
| module = {{Infobox scientist | embed = yes | known_for = Research on chromatin-based and epigenetic mechanisms | thesis_title = Biochemical analysis of MeCP2 | thesis_url = http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.653493 | thesis_year = 2005 | doctoral_advisor = Prof. Sir Adrian Bird | doctoral_students = |awards = {{Plainlist|
| website = {{Plainlist|
EducationKlose was an undergraduate student at the University of Waterloo in Ontario, Canada, where he graduated with Dean's Honors in Biology. As a postgraduate student under Prof. Sir Adrian Bird at the Wellcome Centre for Cell Biology at the University of Edinburgh, Scotland, he studied the methyl CpG binding protein MeCP2, part of the DNA methylation system, which is associated with Rett syndrome.[5] He obtained his Doctor of Philosophy in 2005.[6] Career and researchKlose spent two years as a postdoctoral researcher in the lab of Yi Zhang, who was based at the University of North Carolina at Chapel Hill, identifying a novel family of histone lysine demethylase enzymes.[7][8][9] He then moved to the University of Oxford where, in 2008, he established himself as a Principal Investigator at the Department of Biochemistry at Oxford supported by a Wellcome Trust Career Development Fellowship. Five years after this, he secured a Wellcome Trust Senior Research Fellowship. Since then, he has been a Monsanto Senior Research Fellow, a post associated with Exeter College, Oxford, and in 2014 was appointed as Professor of Cell and Molecular Biology. In 2017 he was appointed Professor of Genetics, a chair held at the Department of Biochemistry and associated with a fellowship at Keble College, Oxford. Klose's work throughout his career has sought to explain how, during development, cell types with the same DNA use chromatin-based and epigenetic mechanisms to restrict gene expression to the correct complement of genes in a stable and heritable way. In particular, he has focused on understanding how DNA encoded regulatory elements in vertebrates, called CpG islands, help to achieve appropriately controlled gene usage. Awards and honoursKlose was selected as a member of the EMBO Young Investigator programme in 2010[10] and was awarded a Lister Institute of Preventive Medicine Research prize in 2011.[11] In recognition of his achievements as an early career stage scientist, he was awarded the Royal Society Francis Crick Lecture in 2015.[12] References1. ^{{cite web|last1=Klose|first1=Rob|title=Professor Rob Klose|url=https://www.bioch.ox.ac.uk/research/klose|website=Department of Biochemistry, University of Oxford|accessdate=6 November 2017}} {{Authority control}}{{DEFAULTSORT:Klose, Rob}}2. ^{{cite journal|last1=Klose|first1=Rob|title=CpG islands recruit a histone H3 lysine 36 demethylase|journal=Mol. Cell|date=2010|volume=38|issue=2|pages=179–90|doi=10.1016/j.molcel.2010.04.009|pmid=20417597|pmc=3098377}} 3. ^{{cite journal|last1=Klose|first1=Rob|title=ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection|journal=Biochem Soc Trans|date=2013|volume=41|issue=3|pages=727–40|doi=10.1042/BST20130028|pmid=23697932|pmc=3685328}} 4. ^{{cite journal|last1=Klose|first1=Rob|title=Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation|journal=Cell|date=2014|volume=157|issue=6|pages=1445–59|doi=10.1016/j.cell.2014.05.004|pmid=24856970|pmc=4048464}} 5. ^{{cite journal|last1=Klose|first1=Rob|title=DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG|journal=Mol. Cell|date=2005|volume=19|issue=5|pages=667–78|doi=10.1016/j.molcel.2005.07.021|pmid=16137622|url=http://www.cell.com/molecular-cell/fulltext/S1097-2765(05)01509-1}} 6. ^{{cite web|last1=Klose|first1=Rob|date=2005|title=Biochemical analysis of MeCP2. Thesis (Ph.D.)|url=http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.653493|website=EThOS|publisher=British Library}} 7. ^{{cite journal|last1=Klose|first1=Rob|title=The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36|journal=Nature|date=2006|volume=442|issue=7100|pages=312–6|doi=10.1038/nature04853|pmid=16732292|url=https://www.nature.com/nature/journal/v442/n7100/full/nature04853.html}} 8. ^{{cite journal|last1=Klose|first1=Rob|title=The retinoblastoma binding protein RBP2 is an H3K4 demethylase|journal=Cell|date=2007|volume=128|issue=5|pages=889–900|doi=10.1016/j.cell.2007.02.013|pmid=17320163|url=http://www.cell.com/cell/fulltext/S0092-8674(07)00194-8}} 9. ^{{cite journal|last1=Klose|first1=Rob|title=Regulation of histone methylation by demethylimination and demethylation|journal=Nat Rev Mol Cell Biol|date=2007|volume=8|issue=4|pages=307–18|doi=10.1038/nrm2143|pmid=17342184|url=https://www.nature.com/nrm/journal/v8/n4/full/nrm2143.html}} 10. ^{{cite web|title=Twenty-one group leaders join network of EMBO Young Investigators|url=http://www.embo.org/news/press-releases/2010/twenty-one-group-leaders-join-network-of-embo-young-investigators|website=EMBO Press release 2010|accessdate=7 November 2017}} 11. ^{{cite web|title=Lister Institute Current Prize Fellows|url=http://paisieres.co.uk/fellows/current-prize-fellows/|website=Lister Institute|accessdate=7 November 2017}} 12. ^{{cite web|title=Gene regulation and the epigenome, Prize lecture on 2 December 2015|url=https://royalsociety.org/science-events-and-lectures/2015/12/francis-crick-lecture/|website=Royal Society|accessdate=7 November 2017}} 6 : Canadian geneticists|Living people|1977 births|Alumni of the University of Edinburgh|University of Waterloo alumni|Professors of Genetics (University of Oxford) |
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