| 词条 | Rostafuroxin |
| 释义 |
| ImageFile = rostafuroxin.svg | ImageSize = 200px | IUPACName = (3S,5R,8R,9S,10S,13S,14S,17S)-17-(Furan-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol | OtherNames = | Section1 = {{Chembox Identifiers | CASNo = 156722-18-8 | PubChem = 153976 | UNII = P848LCX62B | SMILES = C[C@]12CC[C@@H](C[C@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@@]3(CC[C@@]4(C5=COC=C5)O)O)C)O | Section2 = {{Chembox Properties | C=23|H=34|O=4 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = | Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}Rostafuroxin is a digitoxigenin analog that has been shown to lower blood pressure in an animal model of hypertension.[1] It modulates the effects of the enzyme Na+/K+-ATPase,[1] which maintains sodium and potassium ion gradients across plasma membranes. Rostafuroxin is being studied in clinical trials for the treatment of essential hypertension.[2][3] References1. ^1 {{cite journal | doi = 10.1152/ajpregu.00518.2005| pmid = 16467500| title = Rostafuroxin: An ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension| journal = American Journal of Physiology. Regulatory, Integrative and Comparative Physiology| volume = 290| issue = 3| pages = R529–R535| year = 2006| last1 = Ferrari| first1 = Patrizia| last2 = Ferrandi| first2 = Mara| last3 = Valentini| first3 = Giovanni| last4 = Bianchi| first4 = Giuseppe}} {{cardiovascular-drug-stub}}2. ^{{cite journal | doi = 10.1016/j.BBAdis.2010.01.009| pmid = 20083196| title = Rostafuroxin: An ouabain-inhibitor counteracting specific forms of hypertension| journal = Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease| volume = 1802| issue = 12| pages = 1254–1258| year = 2010| last1 = Ferrari| first1 = Patrizia}} 3. ^{{cite web | url = https://clinicaltrials.gov/ct2/show/NCT00415038 | title = Efficacy of Rostafuroxin in the Treatment of Essential Hypertension | publisher = clinicaltrials.gov}} 3 : Furans|Steroids|Antihypertensive agents |
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