| 词条 | (R,R)-Tetrahydrochrysene |
| 释义 |
| drug_name = (R,R)-Tetrahydrochrysene | Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = (5R,11R)-5,11-Diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol | image = Tetrahydrochrysene.svg | width = 250 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 138090-06-9 | CAS_supplemental = | ATC_prefix = | ATC_suffix = | PubChem = 446849 | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 394097 | C=22 | H=24 | O=2 | molecular_weight = 320.42476 g/mol | smiles = CCC1CC2=C(C=CC(=C2)O)C3=C1C4=C(CC3CC)C=C(C=C4)O | StdInChI = 1S/C22H24O2/c1-3-13-9-15-11-17(23)6-8-20(15)22-14(4-2)10-16-12-18(24)5-7-19(16)21(13)22/h5-8,11-14,23-24H,3-4,9-10H2,1-2H3/t13-,14-/m1/s1 | StdInChIKey = MASYAWHPJCQLSW-ZIAGYGMSSA-N | synonyms = }}(R,R)-Tetrahydrochrysene ((R,R)-THC) is a drug used to study the estrogen receptors (ERs) in scientific research. It is an ERβ antagonist and an ERα agonist with 10-fold higher affinity for ERβ relative to ERα.[1][2] (R,R)-THC is a silent antagonist of ERβ,[3] and, uniquely relative to other known ERβ antagonists, a passive antagonist of the receptor.[2](S,S)-Tetrahydrochrysene ((S,S)-THC) also binds to the ERs, but in contrast to (R,R)-THC, (S,S)-THC is an agonist of both ERα and ERβ and has 20-fold lower affinity for ERβ relative to (R,R)-THC.[3] See also
References1. ^{{cite book|author=Ying Chen|title=The Role of Steroids in the Regulation of Oocyte Cyst Breakdown and Primordial Follicle Assembly in the Neonatal Mouse Ovary|url=https://books.google.com/books?id=uf2VdCOO6moC&pg=PA101|year=2008|publisher=ProQuest|isbn=978-0-549-74620-1|pages=101–}} {{Estrogenics}}{{DEFAULTSORT:Tetrahydrochrysene, (R,R)-}}{{pharmacology-stub}}2. ^1 {{cite journal | vauthors = Shiau AK, Barstad D, Radek JT, Meyers MJ, Nettles KW, Katzenellenbogen BS, Katzenellenbogen JA, Agard DA, Greene GL | title = Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism | journal = Nat. Struct. Biol. | volume = 9 | issue = 5 | pages = 359–64 | year = 2002 | pmid = 11953755 | doi = 10.1038/nsb787 | url = }} 3. ^1 {{cite journal | vauthors = Sun J, Meyers MJ, Fink BE, Rajendran R, Katzenellenbogen JA, Katzenellenbogen BS | title = Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta | journal = Endocrinology | volume = 140 | issue = 2 | pages = 800–4 | year = 1999 | pmid = 9927308 | doi = 10.1210/endo.140.2.6480 | url = }} 2 : Estrogens|Antiestrogens |
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