| 词条 | RU-57073 |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = 4-[3-(2-Hydroxyethyl)-4,4-dimethyl-5-oxo-2-sulfanylideneimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile | image = RU-57073.svg | width = 250px | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | class = Nonsteroidal antiandrogen | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 143782-37-0 | CAS_supplemental = | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = 21884237 | IUPHAR_ligand = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = | UNII = | KEGG = | ChEBI = | ChEMBL = | synonyms = | C=15 | H=14 | F=3 | N=3 | O=2 | S=1 | molecular_weight = 357.351 g/mol | SMILES = CC1(C(=O)N(C(=S)N1CCO)C2=CC(=C(C=C2)C#N)C(F)(F)F)C | StdInChI_Ref = | StdInChI = 1S/C15H14F3N3O2S/c1-14(2)12(23)21(13(24)20(14)5-6-22)10-4-3-9(8-19)11(7-10)15(16,17)18/h3-4,7,22H,5-6H2,1-2H3 | StdInChIKey_Ref = | StdInChIKey = HNTMVNIRYPJDDJ-UHFFFAOYSA-N }}RU-57073 is a nonsteroidal antiandrogen which was never marketed.[1][2][3] It shows 163% of the affinity of testosterone for the androgen receptor and negligible affinity for other steroid hormone receptors.[1][2]{{Affinities of a selection of androgen ligands at steroid hormone receptors}} See also
References1. ^1 {{cite journal | vauthors = Singh SM, Gauthier S, Labrie F | title = Androgen receptor antagonists (antiandrogens): structure-activity relationships | journal = Curr. Med. Chem. | volume = 7 | issue = 2 | pages = 211–47 | date = February 2000 | pmid = 10637363 | doi = 10.2174/0929867003375371 | url = }} {{Androgen receptor modulators}}{{Genito-urinary-drug-stub}}2. ^1 {{cite journal | vauthors = Teutsch G, Goubet F, Battmann T, Bonfils A, Bouchoux F, Cerede E, Gofflo D, Gaillard-Kelly M, Philibert D | title = Non-steroidal antiandrogens: synthesis and biological profile of high-affinity ligands for the androgen receptor | journal = J. Steroid Biochem. Mol. Biol. | volume = 48 | issue = 1 | pages = 111–9 | date = January 1994 | pmid = 8136296 | doi = 10.1016/0960-0760(94)90257-7 | url = }} 3. ^{{cite journal | vauthors = Münster U, Nakamura C, Haberland A, Jores K, Mehnert W, Rummel S, Schaller M, Korting HC, Zouboulis CC, Blume-Peytavi U, Schäfer-Korting M | title = RU 58841-myristate--prodrug development for topical treatment of acne and androgenetic alopecia | journal = Pharmazie | volume = 60 | issue = 1 | pages = 8–12 | date = January 2005 | pmid = 15700772 | doi = | url = https://www.ingentaconnect.com/content/govi/pharmaz/2005/00000060/00000001/art00002}} 8 : Abandoned drugs|Alcohols|Ketones|Imidazolines|Nitriles|Nonsteroidal antiandrogens|Organosulfur compounds|Trifluoromethyl compounds |
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