| 词条 | Schradan |
| 释义 |
| Name = Schradan | ImageFile = Schradan.svg | IUPACName = N,N,N′,N′,N′′,N′′,N′′′,N′′′-Octamethyldiphosphoric tetraamide | OtherNames = OMPA, Octamethyl pyrophosphoramide | Section1 = {{Chembox Identifiers | CASNo = 152-16-9 | ChemSpiderID = 8685 | PubChem = 9037 | ChEBI = 82148 | EC_number = 205-801-0 | KEGG = C19015 | RTECS = UX5950000 | UNNumber = 3018 | UNII = D77OYM46S1 | SMILES = CN(C)P(=O)(N(C)C)OP(=O)(N(C)C)N(C)C | StdInChI = InChI=1S/C8H24N4O3P2/c1-9(2)16(13,10(3)4)15-17(14,11(5)6)12(7)8/h1-8H3 | StdInChIKey = SZKKRCSOSQAJDE-UHFFFAOYSA-N }} | Section2 = {{Chembox Properties | C=8|H=24|N=4|O=3|P=2 | Density = 1.09 }} | Section3 = {{Chembox Hazards | MainHazards = Toxic | GHSPictograms = {{GHS06}}{{GHS08}} | GHSSignalWord = Danger | HPhrases = {{H-phrases|300|310|330|371|373|402|412}} | PPhrases = {{P-phrases|260|262|264|270|271|273|280|284|301+310|302+350|304+340|309+311|310|314|320|321|322|330|361|363|403+233|405|501}} }} }}Schradan, named after Gerhard Schrader, is an obsolete organophosphate insecticide.[1] Schradan itself is a weak cholinesterase inhibitor and requires metabolic activation to become active.[2] See also
References1. ^{{cite journal |last1=GARDINER |first1=JE |last2=KILBY |first2=BA |title=Biochemistry of organic phosphorus insecticides. I. The mammalian metabolism of bis(dimethylamino) phosphonous anhydride (Schradan). |journal=The Biochemical Journal |date=April 1952 |volume=51 |issue=1 |pages=78–85 |pmid=14944535 |pmc=1197790}} {{Acetylcholine metabolism and transport modulators}}{{Insecticides}}{{Neurotoxins}}{{Organic-compound-stub}}2. ^{{cite journal |last1=DAVISON |first1=AN |title=The conversion of schra dan (OMPA) and parathion into inhibitors of cholinesterase by mammalian liver. |journal=The Biochemical Journal |date=October 1955 |volume=61 |issue=2 |pages=203–9 |pmid=13260199 |pmc=1215773}} 2 : Acetylcholinesterase inhibitors|Organophosphate insecticides |
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