| 词条 | Allan Maxam |
| 释义 |
|name = Allan Maxam |image = |image_size =150px |caption = |birth_date = {{b-da|October 28, 1942}} |birth_place = |death_date = |death_place = |residence = |citizenship = |nationality = |ethnicity = |field = |work_institutions = |alma_mater = |doctoral_advisor = Walter Gilbert |doctoral_students = |known_for = Maxam–Gilbert sequencing |author_abbrev_bot = |author_abbrev_zoo = |influences = |influenced = |prizes = |religion = |footnotes = |signature = }} Allan Maxam (born October 28, 1942) is one of the pioneers of molecular genetics. He was one of the contributors to develop a DNA sequencing method at Harvard University, while working as a student in the laboratory of Walter Gilbert.[1][2] Walter Gilbert and Allan Maxam developed a DNA sequencing method - now called Maxam-Gilbert sequencing - which combined chemicals that cut DNA only at specific bases with radioactive labeling and polyacrylamide gel electrophoresis to determine the sequence of long DNA segments.[3] Allan Maxam and Walter Gilbert’s 1977 paper “A new method for sequencing DNA” was honored by a Citation for Chemical Breakthrough Award from the Division of History of Chemistry of the American Chemical Society for 2017. It was presented to the Department of Molecular & Cellular Biology, Harvard University.[4][1] References1. ^1 {{Citation|pmid= 265521|last=Maxam|first=A M|last2=Gilbert|first2=W|publication-date=Feb 1977|pmc = 392330|year=1977|title=A new method for sequencing DNA.|volume=74|issue=2|periodical=Proc. Natl. Acad. Sci. U.S.A.|pages=560–4|doi = 10.1073/pnas.74.2.560}} 2. ^DNA SEQUENCING AND GENE STRUCTURE, Walter Gilbert Nobel lecture, 8 December, 1980 3. ^Maxam AM, Gilbert W, Sequencing end-labeled DNA with base-specific chemical cleavages, Methods Enzymol. 1980;65(1):499-560 4. ^{{cite web|title=Citations for Chemical Breakthrough Awards 2017 Awardees|url=http://www.scs.illinois.edu/~mainzv/HIST/awards/CCB-2017_Awardees.php|website=Division of the History of Chemistry|accessdate=12 March 2018}}
See also
4 : 1942 births|Living people|Harvard University alumni|American geneticists |
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