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词条 Shimon Sakaguchi
释义

  1. Biography

  2. Awards and recognition

  3. Publications

  4. References

  5. External links

{{Infobox scientist
| name = Shimon Sakaguchi
坂口 志文
| image = Shimon Sakaguchi cropped 2 Shimon Sakaguchi 201711.jpg
| image_size = 250px
| alt =
| caption = Shimon Sakaguchi
| birth_date = {{birth date and age |1951|1|19|mf=y}}
| birth_place = Shiga Prefecture, Japan
| Date of death =
| Place of death =
| nationality = Japanese
| fields = pathology, immunology
| workplaces =Johns Hopkins University
Stanford University
Scripps Research Institute
RIKEN
University of Tokyo
Osaka University
| degree =MD degree (1976)
Ph.D. (1982)
| education= Kyoto University
| known_for = Regulatory T cells
| awards = William B. Coley Award (2004)
Gairdner Foundation International Award (2015)
Crafoord Prize (2017)
| notes =
| Signature ={{nihongo |Shimon Sakaguchi | 坂口 志文 | Sakaguchi Shimon|born January 19, 1951 in Shiga}} is an immunologist and a Distinguished Professor of Osaka University. He is best known for the discovery of regulatory T cells and to describe their role in the immune system. This discovery is used in the treatment of cancer and autoimmune diseases.

Biography

Sakaguchi studied at the University of Kyoto; he obtained a Master's degree in 1976 and then a Ph.D in 1982. In Kyoto, he continued his study of pathology and immunology. As postdoc, he worked at the Johns Hopkins University and to Stanford University in the United States. In 1989, he began his teaching career and became an assistant professor at the Scripps Research Institute, and then returned to Japan in 1991, where he became a researcher at the RIKEN and director of the Department of Pathology immune Metropolitan Institute Tokyo. In 1999 he became professor of experimental pathology at Kyoto University. Since 2007 he is a teacher in his own laboratory at the Osaka University.

In 2015, the news agency Thomson Reuters signals Shimon Sakaguchi among potential recipients of the Nobel Prize in Physiology or Medicine.[1]

Awards and recognition

  • 2004: William B. Coley Award;[2]
  • 2008: Keio Medical Science Prize;[3]
  • 2009: Medals of Honor (Japan), purple ribbon[4]
  • 2011: Asahi Prize;[5]
  • 2012: Foreign member of the National Academy of Sciences;[6]
  • 2015: Gairdner Foundation International Award.[7]
  • 2017: Crafoord Prize
  • 2017: Person of Cultural Merit

Publications

  • Sakaguchi, N., Takahashi, T., Hata, H., Nomura, T. Tagami, T. Yamazaki, S., Sakihama, T., Matsutani, T., Negishi, I. , Nakatsuru, S., and Sakaguchi, S., "Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice", Nature , No. 426, pp. 454–60, 2003.
  • Sakaguchi, S., "Naturally Arising Regulatory CD4 + T cells for immunologic self-tolelance and negative control of immune responses", Annual Review of Immunology '.
  • Hori, S. Nomura, T., and Sakaguchi, S., "Control of Regulatory T cell development by the transcription factor Foxp3," Science , No. 299 pp. 1057–1061, 2003.
  • Wood, and K. Sakaguchi, S., "Regulatory T cells in transplantation," Nature Review of Immunology No. 3, pp. 199–210, 2003.
  • Shimizu, J. Yamazaki, S. Takahashi, T., Ishida, Y., and Sakaguchi, S., "Stimulation of CD4 + CD25 + Regulatory T cells through GITR breaks immunological self-tolerance 'Nature Immunology' ' No. 3, pp. 135-142, 2002.
  • Sakaguchi, S. Sakaguchi, N. Shimizu, J. Yamazaki, S., Sakihama. T. Itoh, M., Kuniyasu, Y., Nomura, T., Toda and Mr. Takahashi, T., "Immunologic tolerance maintained by CD25 + CD4 + Regulatory T cells: Their role in controlling autoimmunity common, tumor immunity, and transplantation tolerance ',' Immunology Review , No. 182, pp. 18-32, 2001.
  • Sakaguchi, S., "Regulatory T cells: key controllers of immunologic self-tolerance ',' ', No. 101, pp' Cell. '. 455-458, 2000.
  • Takahashi, T. Tagami, T. Yamazaki, S., WEDEN, T., Shimizu, J., Sakaguchi, N., Mak, TW and Sakaguchi, S., "Dominating immunologic self- tolerance maintained by CD25 + CD4 + Regulatory T cells constitutively Expressing CTLA-4. J 'Exp. Med., No. 192, pp. 303-309, 2000.
  • Itoh, M., Takahashi, T., Sakaguchi, N., Kuniyasu, Y. Shimizu, J., Ohtsuka, F. and Sakaguchi, S., "Thymus and autoimmunity. Production of CD25 + CD4 + naturally anergic and suppressive T cells have a key function of the thymus in Maintaining immunologic self-tolerance ',' 'Journal of Immunology' ' No. 162, pp. 5317-5326, 1999.
  • Asano, M., Toda, M., Sakaguchi, N. and Sakaguchi, S., "Autoimmune disease as a consequence of developmental abnormality of a T-cell subpopulation," J. Exp. Med., No 184 {{pp. | 387-396}} 1996.

References

1. ^Announcing the 2015 Citation Laureates by Thomson Reuters.
2. ^William B. Coley Award-Award, Cancer Research Institute '(cancerresearch.org)
3. ^The 2008 Keio Medical Science Prize Awardees, Keiō University
4. ^{{cite web |title=Distinguished Professor Shimon SAKAGUCHI of IFReC awarded Canada Gairdner International Award |date=March 26, 2015 |publisher=Osaka University |url=http://www.osaka-u.ac.jp/en/news/topics/2015/03/20150326_01}}
5. ^The Asahi Prize Asahi Shimbun
6. ^Shimon Sakaguchi National Academy of Sciences
7. ^Shimon Sakaguchi MD, PhD, Gairdner Foundation

External links

{{Portal | Biology | Medicine | Japan}}
  • Osaka University Immunology Frontier Research Center.
{{Authority control}}{{DEFAULTSORT:Sakaguchi, Shimon}}

4 : 1951 births|Living people|Japanese immunologists|Kyoto University alumni

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