“Allene oxide cyclase”的意思、由来-开放百科全书

词条

Allene oxide cyclase

释义

Structural studies
References

{{enzyme
| Name = allene-oxide cyclase
| EC_number = 5.3.99.6
| CAS_number = 118390-59-3
| IUBMB_EC_number = 5/3/99/6
| GO_code = 0046423
| image =
| width =
| caption =
}}

In enzymology, an allene-oxide cyclase ({{EC number|5.3.99.6}}) is an enzyme that belongs to the family of isomerases, specifically a class of other intramolecular oxidoreductases. The systematic name of this enzyme class is (9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate isomerase (cyclizing).

The allene oxide of linolenic acid (i.e., (9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate) is converted by allene oxide cyclase to jasmonic acid ((15Z)-12-oxophyto-10,15-dienoate).^[1]

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1Z8K}}, {{PDB link|1ZVC}}, {{PDB link|2BRJ}}, {{PDB link|2DIO}}, {{PDB link|2GIN}}, and {{PDB link|2Q4I}}.

References

1. ^{{cite journal | vauthors = Schaller A, Stintzi A | title = Enzymes in jasmonate biosynthesis - structure, function, regulation | journal = Phytochemistry | volume = 70 | issue = 13-14 | pages = 1532–8 | date = September 2009 | pmid = 19703696 | doi = 10.1016/j.phytochem.2009.07.032 }}
2. ^{{Cite book|title=Medicinal Natural Products: A Biosynthetic Approach|last=Dewick|first=Paul|publisher=John Wiley & Sons, Ltd.|year=2009|isbn=978-0-470-74168-9|location=United Kingdom|pages=42–53}}

{{cite journal | vauthors = Hamberg M | title = Biosynthesis of 12-oxo-10,15(Z)-phytodienoic acid: identification of an allene oxide cyclase | journal = Biochemical and Biophysical Research Communications | volume = 156 | issue = 1 | pages = 543–50 | date = October 1988 | pmid = 3178850 | doi = 10.1016/S0006-291X(88)80876-3 }}

2 : EC 5.3.99|Enzymes of known structure

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