| 词条 | Sink condition |
| 释义 |
In pharmaceutics, sink condition is a term mostly related to the dissolution testing procedure. It means using a sheer volume of solvent, usually about 5 to 10 times greater than the volume present in the saturated solution of the targeted chemical (often the API, and sometimes the excipients) contained in the dosage form being tested.[1] During the dissolution testing, "sink condition" is a mandatory requirement, otherwise when the concentration begins to get too close to the saturation point, even though the total soluble amount still remains constant, the dissolution rate will gradually begin to reduce in significant amounts, enough to corrupt the test results. .[2][3][4] See also
References1. ^{{cite web|title=Shear Rate & Sink Conditions|url=http://www.labhut.com/education-centre/about-dissolution-testing/shear-rate-sink-conditions.html|website=LabHut|publisher=SMI-LabHut Ltd|accessdate=17 April 2016}} {{Dosage forms|state=expanded}}2. ^{{cite book|author=Ron Liu|title=Water-Insoluble Drug Formulation, Second Edition|url=https://books.google.com/books?id=4cfzT2ZY8hUC&pg=PA73|date=18 January 2008|publisher=CRC Press|isbn=978-1-4200-0955-2|pages=73–4}} 3. ^{{cite book|author1=Tapash K. Ghosh|author2=Bhaskara R. Jasti|title=Theory and Practice of Contemporary Pharmaceutics|url=https://books.google.com/books?id=whiC7aSFLY8C&pg=PA203|date=23 November 2004|publisher=CRC Press|isbn=978-0-203-64447-8|pages=203–4}} 4. ^{{cite book|title=Remington Essentials of Pharmaceutics - Felton, Linda 2012: Remington Essentials of Pharmaceutics - Felton, Linda 2012|url=https://books.google.com/books?id=xYvrAwAAQBAJ&pg=PA65|publisher=booksonline|pages=65–66|id=GGKEY:KQQLT3XT7H1}} 4 : Chemical engineering|Pharmaceutical industry|Drug delivery devices|Dosage forms |
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