| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Small nucleolar RNA host gene 1 is a non-protein coding RNA that in humans is encoded by the SNHG1 gene. [1][2]FunctionThis locus represents a small nucleolar RNA host gene that produces multiple alternatively spliced long non-coding RNAs. This gene is upregulated in cancers and is thought to act as promoter of cell proliferation. This transcript negatively regulates tumor suppressor genes such as tumor protein p53. Expression of this locus may be a marker of tumor progression. [provided by RefSeq, Dec 2017]. References 1. ^{{cite web| title = Entrez Gene: Small nucleolar RNA host gene 1| url = https://www.ncbi.nlm.nih.gov/gene/23642| accessdate = 2018-09-04}}
2. ^{{cite journal |last1=Tycowski |first1=KT |last2=Shu |first2=MD |last3=Steitz |first3=JA |title=A mammalian gene with introns instead of exons generating stable RNA products. |journal=Nature |date=1 February 1996 |volume=379 |issue=6564 |pages=464-6 |doi=10.1038/379464a0 |pmid=8559254}}
Further reading {{refbegin | 2}}- {{cite journal |vauthors=You J, Fang N, Gu J, Zhang Y, Li X, Zu L, Zhou Q |title=Noncoding RNA small nucleolar RNA host gene 1 promote cell proliferation in nonsmall cell lung cancer |journal=Indian J Cancer |volume=51 Suppl 3 |issue= |pages=e99–e102 |date=March 2014 |pmid=25818744 |doi=10.4103/0019-509X.154092 |url=}}
- {{cite journal |vauthors=Yu F, Bracken CP, Pillman KA, Lawrence DM, Goodall GJ, Callen DF, Neilsen PM |title=p53 Represses the Oncogenic Sno-MiR-28 Derived from a SnoRNA |journal=PLoS ONE |volume=10 |issue=6 |pages=e0129190 |date=2015 |pmid=26061048 |pmc=4465335 |doi=10.1371/journal.pone.0129190 |url=}}
- {{cite journal |vauthors=Zhang M, Wang W, Li T, Yu X, Zhu Y, Ding F, Li D, Yang T |title=Long noncoding RNA SNHG1 predicts a poor prognosis and promotes hepatocellular carcinoma tumorigenesis |journal=Biomed. Pharmacother. |volume=80 |issue= |pages=73–79 |date=May 2016 |pmid=27133041 |doi=10.1016/j.biopha.2016.02.036 |url=}}
- {{cite journal |vauthors=Sahu D, Hsu CL, Lin CC, Yang TW, Hsu WM, Ho SY, Juan HF, Huang HC |title=Co-expression analysis identifies long noncoding RNA SNHG1 as a novel predictor for event-free survival in neuroblastoma |journal=Oncotarget |volume=7 |issue=36 |pages=58022–58037 |date=September 2016 |pmid=27517149 |pmc=5295409 |doi=10.18632/oncotarget.11158 |url=}}
- {{cite journal |vauthors=Zhang H, Zhou D, Ying M, Chen M, Chen P, Chen Z, Zhang F |title=Expression of Long Non-Coding RNA (lncRNA) Small Nucleolar RNA Host Gene 1 (SNHG1) Exacerbates Hepatocellular Carcinoma Through Suppressing miR-195 |journal=Med. Sci. Monit. |volume=22 |issue= |pages=4820–4829 |date=December 2016 |pmid=27932778 |pmc=5167104 |doi= |url=}}
- {{cite journal |vauthors=Zhu H, Zhang L, Yan S, Li W, Cui J, Zhu M, Xia N, Yang Y, Yuan J, Chen X, Luo J, Chen R, Xing R, Lu Y, Wu N |title=LncRNA16 is a potential biomarker for diagnosis of early-stage lung cancer that promotes cell proliferation by regulating the cell cycle |journal=Oncotarget |volume=8 |issue=5 |pages=7867–7877 |date=January 2017 |pmid=27999202 |pmc=5352366 |doi=10.18632/oncotarget.13980 |url=}}
- {{cite journal |vauthors=Cui Y, Zhang F, Zhu C, Geng L, Tian T, Liu H |title=Upregulated lncRNA SNHG1 contributes to progression of non-small cell lung cancer through inhibition of miR-101-3p and activation of Wnt/β-catenin signaling pathway |journal=Oncotarget |volume=8 |issue=11 |pages=17785–17794 |date=March 2017 |pmid=28147312 |pmc=5392286 |doi=10.18632/oncotarget.14854 |url=}}
- {{cite journal |vauthors=Shen Y, Liu S, Fan J, Jin Y, Tian B, Zheng X, Fu H |title=Nuclear retention of the lncRNA SNHG1 by doxorubicin attenuates hnRNPC-p53 protein interactions |journal=EMBO Rep. |volume=18 |issue=4 |pages=536–548 |date=April 2017 |pmid=28264987 |pmc=5376760 |doi=10.15252/embr.201643139 |url=}}
- {{cite journal |vauthors=Li J, Zhang Z, Xiong L, Guo C, Jiang T, Zeng L, Li G, Wang J |title=SNHG1 lncRNA negatively regulates miR-199a-3p to enhance CDK7 expression and promote cell proliferation in prostate cancer |journal=Biochem. Biophys. Res. Commun. |volume=487 |issue=1 |pages=146–152 |date=May 2017 |pmid=28400279 |doi=10.1016/j.bbrc.2017.03.169 |url=}}
{{refend}}{{gene-11-stub}}{{NLM content}} |