| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Sorting nexin 10 is a protein that in humans is encoded by the SNX10 gene. [1]FunctionThis gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants. References 1. ^{{cite web| title = Entrez Gene: Sorting nexin 10| url = https://www.ncbi.nlm.nih.gov/gene/29887| accessdate = 2017-05-19}}
Further reading {{refbegin | 2}}- {{cite journal |vauthors=Qin B, He M, Chen X, Pei D |title=Sorting nexin 10 induces giant vacuoles in mammalian cells |journal=J. Biol. Chem. |volume=281 |issue=48 |pages=36891–6 |year=2006 |pmid=17012226 |doi=10.1074/jbc.M608884200 |url=}}
- {{cite journal |vauthors=Chen Y, Wu B, Xu L, Li H, Xia J, Yin W, Li Z, Shi D, Li S, Lin S, Shu X, Pei D |title=A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo |journal=Cell Res. |volume=22 |issue=2 |pages=333–45 |year=2012 |pmid=21844891 |pmc=3271581 |doi=10.1038/cr.2011.134 |url=}}
- {{cite journal |vauthors=Zhu CH, Morse LR, Battaglino RA |title=SNX10 is required for osteoclast formation and resorption activity |journal=J. Cell. Biochem. |volume=113 |issue=5 |pages=1608–15 |year=2012 |pmid=22174188 |doi=10.1002/jcb.24029 |url=}}
- {{cite journal |vauthors=Aker M, Rouvinski A, Hashavia S, Ta-Shma A, Shaag A, Zenvirt S, Israel S, Weintraub M, Taraboulos A, Bar-Shavit Z, Elpeleg O |title=An SNX10 mutation causes malignant osteopetrosis of infancy |journal=J. Med. Genet. |volume=49 |issue=4 |pages=221–6 |year=2012 |pmid=22499339 |doi=10.1136/jmedgenet-2011-100520 |url=}}
- {{cite journal |vauthors=Pangrazio A, Fasth A, Sbardellati A, Orchard PJ, Kasow KA, Raza J, Albayrak C, Albayrak D, Vanakker OM, De Moerloose B, Vellodi A, Notarangelo LD, Schlack C, Strauss G, Kühl JS, Caldana E, Lo Iacono N, Susani L, Kornak U, Schulz A, Vezzoni P, Villa A, Sobacchi C |title=SNX10 mutations define a subgroup of human autosomal recessive osteopetrosis with variable clinical severity |journal=J. Bone Miner. Res. |volume=28 |issue=5 |pages=1041–9 |year=2013 |pmid=23280965 |doi=10.1002/jbmr.1849 |url=}}
- {{cite journal |vauthors=Xu J, Xu T, Wu B, Ye Y, You X, Shu X, Pei D, Liu J |title=Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation |journal=J. Biol. Chem. |volume=288 |issue=23 |pages=16598–605 |year=2013 |pmid=23615901 |pmc=3675595 |doi=10.1074/jbc.M112.449306 |url=}}
- {{cite journal |vauthors=Xu T, Xu J, Ye Y, Wang Q, Shu X, Pei D, Liu J |title=Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis |journal=Proteins |volume=82 |issue=12 |pages=3483–9 |year=2014 |pmid=25212774 |doi=10.1002/prot.24689 |url=}}
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