“Alpha-1B adrenergic receptor”的意思、由来-开放百科全书

The alpha-1B adrenergic receptor (α_1B adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.^[1]

Receptor

There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

Gene

This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.^[1]

Ligands

Interactions

Alpha-1B adrenergic receptor has been shown to interact with AP2M1.^[3] A role in regulation of dopaminergic neurotransmission has also been suggested.^[4]^[5]

Further reading

{{cite journal | vauthors=Ramarao CS, Denker JM, Perez DM |title=Genomic organization and expression of the human alpha 1B-adrenergic receptor. |journal=J. Biol. Chem. |volume=267 |issue= 30 |pages= 21936–45 |year= 1992 |pmid= 1328250 |doi= |display-authors=etal}}

{{cite journal | vauthors=Allen LF, Lefkowitz RJ, Caron MG, Cotecchia S |title=G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 24 |pages= 11354–8 |year= 1992 |pmid= 1662393 |doi=10.1073/pnas.88.24.11354 | pmc=53133 |url=https://dukespace.lib.duke.edu/dspace/bitstream/10161/7850/1/Allen_G%20protein%20coupled%20receptor%20genes%20as%20protooncogenes_constitutively%20activating%20mutation.pdf }}

{{cite journal | vauthors=Lomasney JW, Cotecchia S, Lorenz W |title=Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5 |journal=J. Biol. Chem. |volume=266 |issue= 10 |pages= 6365–9 |year= 1991 |pmid= 1706716 |doi= |display-authors=etal}}

{{cite journal | vauthors=Yang-Feng TL, Xue FY, Zhong WW |title=Chromosomal organization of adrenergic receptor genes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 4 |pages= 1516–20 |year= 1990 |pmid= 2154750 |doi=10.1073/pnas.87.4.1516 | pmc=53506 |display-authors=etal}}

{{cite journal | vauthors=Schwinn DA, Johnston GI, Page SO |title=Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues |journal=J. Pharmacol. Exp. Ther. |volume=272 |issue= 1 |pages= 134–42 |year= 1995 |pmid= 7815325 |doi= |display-authors=etal}}

{{cite journal | vauthors=Weinberg DH, Trivedi P, Tan CP |title=Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c |journal=Biochem. Biophys. Res. Commun. |volume=201 |issue= 3 |pages= 1296–304 |year= 1994 |pmid= 8024574 |doi=10.1006/bbrc.1994.1845 |display-authors=etal}}

{{cite journal | vauthors=Forray C, Bard JA, Wetzel JM |title=The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype |journal=Mol. Pharmacol. |volume=45 |issue= 4 |pages= 703–8 |year= 1994 |pmid= 8183249 |doi= |display-authors=etal}}

{{cite journal | vauthors=Diviani D, Lattion AL, Larbi N |title=Effect of different G protein-coupled receptor kinases on phosphorylation and desensitization of the alpha1B-adrenergic receptor |journal=J. Biol. Chem. |volume=271 |issue= 9 |pages= 5049–58 |year= 1996 |pmid= 8617782 |doi=10.1074/jbc.271.9.5049 |display-authors=etal}}

{{cite journal | vauthors=Diviani D, Lattion AL, Cotecchia S |title=Characterization of the phosphorylation sites involved in G protein-coupled receptor kinase- and protein kinase C-mediated desensitization of the alpha1B-adrenergic receptor |journal=J. Biol. Chem. |volume=272 |issue= 45 |pages= 28712–9 |year= 1997 |pmid= 9353340 |doi=10.1074/jbc.272.45.28712 }}

{{cite journal | vauthors=Qian A, Wang W, Sanborn BM |title=Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11) |journal=Cell. Signal. |volume=10 |issue= 2 |pages= 101–5 |year= 1998 |pmid= 9481484 |doi=10.1016/S0898-6568(97)00097-1 }}

{{cite journal | vauthors=Sasaguri T, Teruya H, Ishida A |title=Linkage between alpha(1) adrenergic receptor and the Jak/STAT signaling pathway in vascular smooth muscle cells |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 1 |pages= 25–30 |year= 2000 |pmid= 10652206 |doi= 10.1006/bbrc.1999.2066 |display-authors=etal}}

{{cite journal | vauthors=Minneman KP, Lee D, Zhong H |title=Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes |journal=J. Neurochem. |volume=74 |issue= 6 |pages= 2392–400 |year= 2000 |pmid= 10820200 |doi=10.1046/j.1471-4159.2000.0742392.x |display-authors=etal}}

{{cite journal | vauthors=Shibata K, Katsuma S, Koshimizu T |title=alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1 |journal=J. Biol. Chem. |volume=278 |issue= 1 |pages= 672–8 |year= 2003 |pmid= 12409310 |doi= 10.1074/jbc.M201375200 |display-authors=etal}}

{{cite journal | vauthors=Diviani D, Lattion AL, Abuin L |title=The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis |journal=J. Biol. Chem. |volume=278 |issue= 21 |pages= 19331–40 |year= 2003 |pmid= 12644451 |doi= 10.1074/jbc.M302110200 |display-authors=etal}}

{{cite journal | vauthors=Gonzalez-Cabrera PJ, Gaivin RJ, Yun J |title=Genetic profiling of alpha 1-adrenergic receptor subtypes by oligonucleotide microarrays: coupling to interleukin-6 secretion but differences in STAT3 phosphorylation and gp-130 |journal=Mol. Pharmacol. |volume=63 |issue= 5 |pages= 1104–16 |year= 2003 |pmid= 12695539 |doi=10.1124/mol.63.5.1104 |display-authors=etal}}

{{cite journal | vauthors=Pupo AS, Minneman KP |title=Specific interactions between gC1qR and alpha1-adrenoceptor subtypes |journal=J. Recept. Signal Transduct. Res. |volume=23 |issue= 2–3 |pages= 185–95 |year= 2004 |pmid= 14626446 |doi=10.1081/RRS-120025200 }}

{{cite journal | vauthors=Hague C, Uberti MA, Chen Z |title=Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 15541–9 |year= 2004 |pmid= 14736874 |doi= 10.1074/jbc.M314014200 |display-authors=etal}}

{{cite journal | vauthors=Kang SK, Yi KS, Kwon NS |title=Alpha1B-adrenoceptor signaling and cell motility: GTPase function of Gh/transglutaminase 2 inhibits cell migration through interaction with cytoplasmic tail of integrin alpha subunits |journal=J. Biol. Chem. |volume=279 |issue= 35 |pages= 36593–600 |year= 2004 |pmid= 15220331 |doi= 10.1074/jbc.M402084200 |display-authors=etal}}

{{cite journal | vauthors=Gonzalez-Cabrera PJ, Shi T, Yun J |title=Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes |journal=Endocrinology |volume=145 |issue= 11 |pages= 5157–67 |year= 2004 |pmid= 15297446 |doi= 10.1210/en.2004-0728 |display-authors=etal}}

{{cite journal | vauthors=Zhang T, Xu Q, Chen FR |title=Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors |journal=Acta Pharmacol. Sin. |volume=25 |issue= 11 |pages= 1471–8 |year= 2005 |pmid= 15525470 |doi= |display-authors=etal}}

1 : Adrenergic receptors

Receptor

Gene

Ligands

Interactions

See also

References

External links

Further reading