| 词条 | Spiroxasone |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3-oxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate | image = Spiroxasone.png | width = 250 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = Oral | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 6673-97-8 | CAS_supplemental = | class = | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = 23141 | IUPHAR_ligand = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 21652 | UNII = 8P0U2ZA1NQ | KEGG = D05912 | ChEBI = | ChEMBL = 2105514 | C=24 | H=34 | O=3 | S=1 | molecular_weight = 402.593 g/mol | SMILES = CC(=O)S[C@@H]1CC2=CC(=O)CC[C@@]2([C@@H]3[C@@H]1[C@@H]4CC[C@]5([C@]4(CC3)C)CCCO5)C | StdInChI_Ref = | StdInChI = 1S/C24H34O3S/c1-15(25)28-20-14-16-13-17(26)5-9-22(16,2)18-6-10-23(3)19(21(18)20)7-11-24(23)8-4-12-27-24/h13,18-21H,4-12,14H2,1-3H3/t18-,19-,20+,21+,22-,23-,24-/m0/s1 | StdInChIKey_Ref = | StdInChIKey = XKCGICBTWRNUCL-KIEAKMPYSA-N | synonyms = }}Spiroxasone (INN, USAN) is a synthetic, steroidal antimineralocorticoid of the spirolactone group which was developed as a diuretic and antihypertensive agent but was never marketed.[1][2] It was synthesized and assayed in 1963.[1] The drug is 7α-acetylthiospirolactone with the ketone group removed from the C17α spirolactone ring.[1] Similarly to other spirolactones like spironolactone, spiroxasone also possesses antiandrogen activity.[3][4] References1. ^1 2 {{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA1114|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=1114–}} {{Androgen receptor modulators}}{{Mineralocorticoid receptor modulators}}{{steroid-stub}}{{cardiovascular-drug-stub}}2. ^{{cite book|author1=I.K. Morton|author2=Judith M. Hall|title=Concise Dictionary of Pharmacological Agents: Properties and Synonyms|url=https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA261|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-94-011-4439-1|pages=261–}} 3. ^{{cite book|title=Progress in Medicinal Chemistry|url=https://books.google.com/books?id=wesIAirSEDkC&pg=PA69|date=1 January 1979|publisher=Elsevier|isbn=978-0-08-086264-4|pages=69–|quote=Spiroxasone [...] is also an anti-androgen [379].}} 4. ^{{cite journal | vauthors = Rasmusson GH, Chen A, Reynolds GF, Patanelli DJ, Patchett AA, Arth GE | title = Antiandrogens. 2',3' -Tetrahydrofuran-2'spiro-17-(1,2 -methylene-4-androsten-3-ones) | journal = J. Med. Chem. | volume = 15 | issue = 11 | pages = 1165–8 | year = 1972 | pmid = 4654667 | doi = | url = }} 8 : Abandoned drugs|Acetate esters|Antimineralocorticoids|Furans|Pregnanes|Spiro compounds|Steroidal antiandrogens|Thioesters |
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