| 词条 | Spitz (protein) |
| 释义 |
| Name = Spitz | caption = | image = | width = 150 px | Symbol = SPI | AltSymbols = | EntrezGene = 35253 | RefSeq = NM_057561 | UniProt = Q01083 | PDB = 3LTF | Chromosome = | Arm = | Band = | LocusSupplementaryData = }}Spitz is a protein in fruit flies which is the major activator of Epidermal Growth Factor Receptor (EGFR).[1] FunctionSpitz is produced as a transmembrane protein in the endoplasmic reticulum. There it associates with a cargo receptor called Star and is trafficked to the Golgi. In the Golgi, Spitz is cleaved by a protease called Rhomboid, which releases Spitz to be trafficked to the cell membrane and released out of the cell.[1] From here it can bind EGFR on the surface of other cells, activating the receptor. Alternatively, Spitz can be bound and inactivated by Argos, inhibiting EGFR activation.[2] StructureSpitz is structurally similar to TGF-α.[1] References1. ^1 2 {{cite journal | vauthors = Shilo BZ | title = Signaling by the Drosophila epidermal growth factor receptor pathway during development | journal = Experimental Cell Research | volume = 284 | issue = 1 | pages = 140–9 | year = 2003 | pmid = 12648473 | doi = 10.1016/S0014-4827(02)00094-0 }} 2. ^{{cite journal | vauthors = Klein DE, Nappi VM, Reeves GT, Shvartsman SY, Lemmon MA | title = Argos inhibits epidermal growth factor receptor signalling by ligand sequestration | journal = Nature | volume = 430 | issue = 7003 | pages = 1040–4 | year = 2004 | pmid = 15329724 | doi = 10.1038/nature02840 }} External links
1 : Drosophila melanogaster genes |
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