| 词条 | S-SodF RNA |
| 释义 |
| Name = SodF sRNA | image = RF02790.svg | width = | caption = Predicted secondary structure and sequence conservation of SodF small RNA | Symbol = | AltSymbols = | Rfam = RF02790 | miRBase = | miRBase_family = | RNA_type = | Tax_domain = Bacteria | GO = {{GO|017148}}, {{GO|0003729}}, {{GO|0043488}} | SO = {{SO|0000370}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }}s-SodF RNA is a non-coding RNA (ncRNA) molecule identified in Streptomyces coelicolor. It is produced from sodF mRNA by cleavage of about 90 nucleotides from its 3'UTR. However it does not affect the function of sodF mRNA, but It acts on another mRNA called sodN. s-SodF RNA has a sequence complimentary to sodN mRNA from the 5'-end up to the ribosome binding site. It pairs with sodN mRNA, blocks its translation and facilitates sodN mRNA decay.[1] In Streptomyces sodF and sodN genes produce FeSOD and NiSOD superoxide dismutases containing Fe and Ni respectively. Their expression is inversely regulated by nickel-specific Fur-family regulator called Nur. When Ni is present Nur directly represses sodF transcription, and indirectly induces sodN.[2][3][4][5][6] References1. ^{{Cite journal|last=Kim|first=Hae Mi|last2=Shin|first2=Jung-Ho|last3=Cho|first3=Yoo-Bok|last4=Roe|first4=Jung-Hye|date=February 2014|title=Inverse regulation of Fe- and Ni-containing SOD genes by a Fur family regulator Nur through small RNA processed from 3'UTR of the sodF mRNA|journal=Nucleic Acids Research|volume=42|issue=3|pages=2003–2014|doi=10.1093/nar/gkt1071|issn=1362-4962|pmc=3919588|pmid=24234448}} {{molecular-cell-biology-stub}}2. ^{{Cite journal|last=Kim|first=E. J.|last2=Chung|first2=H. J.|last3=Suh|first3=B.|last4=Hah|first4=Y. C.|last5=Roe|first5=J. H.|date=April 1998|title=Expression and regulation of the sodF gene encoding iron- and zinc-containing superoxide dismutase in Streptomyces coelicolor Müller|journal=Journal of Bacteriology|volume=180|issue=8|pages=2014–2020|issn=0021-9193|pmid=9555880}} 3. ^{{Cite journal|last=Kim|first=E. J.|last2=Chung|first2=H. J.|last3=Suh|first3=B.|last4=Hah|first4=Y. C.|last5=Roe|first5=J. H.|date=January 1998|title=Transcriptional and post-transcriptional regulation by nickel of sodN gene encoding nickel-containing superoxide dismutase from Streptomyces coelicolor Müller|journal=Molecular Microbiology|volume=27|issue=1|pages=187–195|issn=0950-382X|pmid=9466266}} 4. ^{{Cite journal|last=Ahn|first=Bo-Eun|last2=Cha|first2=Joonseok|last3=Lee|first3=Eun-Jin|last4=Han|first4=Ah-Reum|last5=Thompson|first5=Charles J.|last6=Roe|first6=Jung-Hye|date=March 2006|title=Nur, a nickel-responsive regulator of the Fur family, regulates superoxide dismutases and nickel transport in Streptomyces coelicolor|journal=Molecular Microbiology|volume=59|issue=6|pages=1848–1858|doi=10.1111/j.1365-2958.2006.05065.x|issn=0950-382X|pmid=16553888}} 5. ^{{Cite journal|last=An|first=Young Jun|last2=Ahn|first2=Bo-Eun|last3=Han|first3=A.-Reum|last4=Kim|first4=Hae-Mi|last5=Chung|first5=Kyung Min|last6=Shin|first6=Jung-Ho|last7=Cho|first7=Yoo-Bok|last8=Roe|first8=Jung-Hye|last9=Cha|first9=Sun-Shin|date=June 2009|title=Structural basis for the specialization of Nur, a nickel-specific Fur homolog, in metal sensing and DNA recognition|journal=Nucleic Acids Research|volume=37|issue=10|pages=3442–3451|doi=10.1093/nar/gkp198|issn=1362-4962|pmc=2691836|pmid=19336416}} 6. ^{{Cite journal|last=Chung|first=H. J.|last2=Choi|first2=J. H.|last3=Kim|first3=E. J.|last4=Cho|first4=Y. H.|last5=Roe|first5=J. H.|date=December 1999|title=Negative regulation of the gene for Fe-containing superoxide dismutase by an Ni-responsive factor in Streptomyces coelicolor|journal=Journal of Bacteriology|volume=181|issue=23|pages=7381–7384|issn=0021-9193|pmid=10572144}} 1 : Non-coding RNA |
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