| 词条 | Stephen Tsang |
| 释义 |
| name = Stephen H. Tsang | native_name = 曾慶霖 | native_name_lang = zh | image = | image_size = | alt = | caption = | birth_date = | birth_place = | death_date = | death_place = | death_cause = | resting_place = | resting_place_coordinates = | other_names = | residence = United States | citizenship = | nationality = | fields = ophthalmology, genetics | workplaces = Columbia University Medical Center | patrons = | education = Johns Hopkins University (B.S.), Columbia College of Physicians and Surgeons (M.D.-Ph.D.) | alma_mater = | thesis_title = | thesis_url = | thesis_year = | doctoral_advisor = | academic_advisors = | doctoral_students = | notable_students = | known_for = Successfully treated preclinical models of Pde6a, Pde6b, Mfrp, and autosomal recessive bestrophinopathy retinopathies | influences = | influenced = | awards = | author_abbrev_bot = | author_abbrev_zoo = | spouse = | partner = | children = | signature = | signature_alt = | website = | footnotes = }}Stephen H. Tsang (Chinese: 曾慶霖; Pinyin: Zeng Qing-Lin) is an ophthalmologist and geneticist. He is currently an Associate Professor of Ophthalmology and an Associate Professor of Cell Biology and Pathology at Columbia University Medical Center in New York City, New York, in the United States.[1] Tsang studies metabolic signaling in retinal diseases, as well as gene therapy and stem cell therapy to treat such diseases.[2][3][4] In 2010, Tsang led an international research team that used embryonic stem cells of mice to replace diseased retinal cells in mice with retinitis pigmentosa to restore sight.[5] In 2012, Tsang produced long term visual improvement in retinitis pigmentosa mouse models in two experiments, one using induced pluripotent stem cells and the other gene therapy.[6] In 2015, Tsang was among the leaders of a team which discovered a gene mutation that can cause achromatopsia.[1] In 2016, Tsang's team, in partnership with University of Iowa scientists, used the genome editing tool called CRISPR to repair a mutation that causes retinitis pigmentosa in patient derived stem cells.[7][8] In 2018, Tsang and his team created a new technique for CRISPR, restoring function in the retina of mice affected by retinitis pigmentosa.[3][9] BiographyTsang is of Cantonese descent and immigrated to the United States after high school, graduating college from Johns Hopkins University.[10] During college, Tsang trained in medical genetics under Professor Victor A. McKusick.[11] He obtained an M.D.-Ph.D. from the NIH-National Institute of General Medical Sciences Medical Scientist Training Program at Columbia University.[11] Tsang did his residency at Jules Stein Eye Institute/UCLA, and then he studied with Professors Alan C. Bird and Graham E. Holder, researching how to improve care of people suffering macular degeneration.[1] Tsang is the editor of two books on regenerative medicine and precision medicine.[12][13][14] He has authored over 280 peer reviewed articles, including articles published in Science and Journal of Clinical Investigation.[15] Selected Honors
References1. ^1 2 3 {{Cite news|url=https://www.pathology.columbia.edu/profile/stephen-h-tsang-md|title=Stephen H. Tsang, MD, PhD|date=2017-06-21|work=Pathology|access-date=2018-07-11|language=en}} 2. ^{{Cite news|url=https://www.nbcnews.com/mach/science/scientists-foresee-fixes-even-complicated-forms-blindness-ncna805221|title=Scientists foresee fixes even for complicated forms of blindness|work=NBC News|access-date=2018-07-11|language=en-US}} 3. ^1 2 {{Cite web|url=https://www.aao.org/newsroom/news-releases/detail/genome-surgery-eye-disease-moves-closer-to-reality|title=Genome Surgery for Eye Disease Moves Closer to Reality - American Academy of Ophthalmology|website=www.aao.org|access-date=2018-07-11}} 4. ^{{Cite web|url=https://stemcell.ny.gov/stephen-tsang|title=Stephen Tsang {{!}} NYSTEM|website=stemcell.ny.gov|language=en|access-date=2018-07-11}} 5. ^{{Cite web|url=http://www.cumc.columbia.edu/publications/press_releases/Stem_Cells_Retinitis_Pigmentosa.html|title=Columbia University Medical Center Press Release|website=www.cumc.columbia.edu|language=en-us|access-date=2018-07-11}} 6. ^{{Cite news|url=http://newsroom.cumc.columbia.edu/blog/2012/12/20/two-treatments-for-retinitis-pigmentosa-move-closer-to-clinical-trials/|title=Two Treatments for Retinitis Pigmentosa Move Closer to Clinical Trials - Columbia University Medical Center|date=2012-12-20|work=Columbia University Medical Center|access-date=2018-07-11|language=en-US}} 7. ^{{Cite web|url=https://stemcell.ny.gov/press-release/combination-stem-cells-and-gene-modifying-tools-provide-path|title=Combination of Stem Cells and Gene Modifying Tools Provide Path to Vision Repair {{!}} NYSTEM|website=stemcell.ny.gov|language=en|access-date=2018-07-11}} 8. ^{{Cite news|url=https://www.forbes.com/sites/emilymullin/2016/01/29/crispr-used-to-repair-blindness-causing-gene-defect/#17f805ff46a7|title=CRISPR Used To Repair Blindness-Causing Gene Defect|last=Mullin|first=Emily|work=Forbes|access-date=2018-07-19|language=en}} 9. ^{{Cite web|url=http://www.cumc.columbia.edu/publications/press_releases/Stem_Cells_Retinitis_Pigmentosa.html|title=Columbia University Medical Center Press Release|website=www.cumc.columbia.edu|language=en-us|access-date=2018-07-11}} 10. ^{{Cite news|url=http://www.igm.columbia.edu/profile/shtsang|title=Stephen H. Tsang, MD, PhD|work=Institute of Genomic Medicine|access-date=2018-07-11|language=en}} 11. ^1 {{Cite web|url=https://www.columbiaeye.org/profile/shtsang?profile=provider|title=Columbia Ophthalmology|website=www.columbiaeye.org|language=en|access-date=2018-07-11}} 12. ^{{Cite book|url=https://www.springer.com/us/book/9783319639031|title=Precision Medicine, CRISPR, and Genome Engineering - Moving from Association to Biology and Therapeutics {{!}} Stephen Tsang {{!}} Springer|language=en}} 13. ^{{Cite news|url=https://www.stemcell.columbia.edu/recent-book-publication-edited-dr-stephen-tsang|title=Recent book publication edited by Dr. Stephen Tsang|date=2017-12-05|work=Columbia Stem Cell Initiative - CSCI|access-date=2018-07-11|language=en}} 14. ^{{Cite book|url=https://www.springer.com/la/book/9781461454922|title=Stem Cell Biology and Regenerative Medicine in Ophthalmology {{!}} Stephen Tsang {{!}} Springer|language=en}} 15. ^{{Cite web|url=https://www.ncbi.nlm.nih.gov/pubmed/?term=tsang+sh|title=tsang sh - PubMed - NCBI|last=pubmeddev|website=www.ncbi.nlm.nih.gov|language=en|access-date=2018-07-13}} 16. ^{{Cite web|url=https://www.uclahealth.org/eye/workfiles/news/EYE%20Newsletter/EYEFall2016.pdf|title=Stein Eye Institute 50 Years of Vision: Patient Care|last=|first=|date=|website=UCLA Health|access-date=}} 17. ^{{Cite web|url=http://cancer.columbia.edu/stephen-h-tsang-md-phd|title=Stephen H. Tsang, MD, PhD {{!}} Herbert Irving Comprehensive Cancer Center|website=cancer.columbia.edu|language=en|access-date=2018-07-13}} 18. ^{{Cite web|url=https://aupo.org/about-aupo/history|title=History {{!}} Association of University Professors of Ophthalmology|website=aupo.org|language=en|access-date=2018-07-13}} 19. ^{{Cite web|url=https://www.arvo.org/contentassets/3dfd090d81564db08fdd6fb634236c58/past-recipient-list---alcon-early-career-clinician-scientist-awards.pdf|title=ARVO/Alcon Early Career Clinician-Scientist Research Awards|last=|first=|date=|website=ARVO Foundation|access-date=}} 20. ^{{Cite web|url=http://arvo-prod.serverside.net/foundation/Awards_and_Grants/Recipient_history/|title=Recipient history|website=arvo-prod.serverside.net|access-date=2018-07-13}} 21. ^{{Cite web|url=https://www.curechm.org/research/science-advisory-board/stephen-tsang-md-phd|title=Stephen Tsang, MD PhD {{!}} Choroideremia Research Foundation|website=www.curechm.org|language=en|access-date=2018-07-13}} 22. ^{{Cite web|url=https://www.the-asci.org/controllers/asci/AsciProfileController.php?pid=501412|title=Member Directory|last=|first=|date=|website=The American Society for Clinical Investigation|access-date=}} 23. ^{{Cite web|url=http://www.maculasociety.org/awardslectures|title=Awards & Lectures|website=www.maculasociety.org|language=en|access-date=2018-07-13}} 24. ^{{Cite web|url=https://www.vitals.com/doctors/Dr_Stephen_Tsang/credentials|title=Credentials {{!}} Dr. Stephen H Tsang MD Reviews {{!}} New York, NY {{!}} Vitals.com|website=www.vitals.com|language=en|access-date=2018-07-16}} }}{{Authority control}}{{DEFAULTSORT:Tsang, Stephen}} 4 : American medical academics|Year of birth missing (living people)|Living people|American ophthalmologists |
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