| 词条 | Stuart Orkin |
| 释义 |
| name = Stuart H. Orkin | native_name = | native_name_lang = | image = | image_size = | alt = | caption = | birth_date = | birth_place = | death_date = | death_place = | death_cause = | resting_place = | resting_place_coordinates = | other_names = | residence = | citizenship = | nationality = American | fields = Pediatric oncology | workplaces = Dana–Farber/Harvard Cancer Center | patrons = | education = Massachusetts Institute of Technology, Harvard Medical School | alma_mater = | thesis_title = | thesis_url = | thesis_year = | doctoral_advisor = | academic_advisors = | doctoral_students = | notable_students = | known_for = | influences = | influenced = | awards = | author_abbrev_bot = | author_abbrev_zoo = | signature = | signature_alt = | website = | footnotes = }} Stuart H. Orkin is an American physician, stem cell biologist and researcher in pediatric hematology-oncology. He is the David G. Nathan Distinguished Professor of Pediatrics at Harvard Medical School. Orkin's research has focused on the genetic basis of blood disorders. He is a member of the National Academy of Sciences and the Institute of Medicine, and an Investigator of the Howard Hughes Medical Institute. Early lifeOrkin grew up in Manhattan, where his father was a urologist. He studied biology as an undergraduate at the Massachusetts Institute of Technology and earned a medical degree from Harvard Medical School. He did postdoctoral research in molecular biology at the National Institutes of Health under geneticist Philip Leder. While Orkin was completing his training in hematology-oncology, his department chair, David G. Nathan, allowed him to establish his own research laboratory.[1] CareerOrkin is the David G. Nathan Distinguished Professor of Pediatrics at Harvard Medical School. He served as Chair of the Department of Pediatric Oncology at the Dana–Farber/Harvard Cancer Center from 2000-2016.[2] He has been on the Harvard Medical School faculty since the late 1970s and has been a Howard Hughes Medical Institute investigator since 1986.[3][4] In the 1970s and 1980s, Orkin conducted research that identified genetic mutations associated with a group of blood disorders known as the thalassemias.[5] This work led to the first comprehensive description of molecular defects in an inherited disorder. Later (1986), he and his team cloned a gene causing chronic granulomatous disease, marking the first time that a disease-causing gene was cloned without the researchers already knowing the protein coded by the gene.[5] Today, his research lab examines transcriptional regulators of cell specification and differentiation.[5] HIs laboratory cloned the first hematopoietic transcription factor GATA1 (1989). Starting in 2008, Orkin and his colleagues published a series of papers identifying the critical role for BCL11A in the developmental switch from fetal type (HbF) to adult type (HbA) hemoglobin. His group demonstrated that loss of BCL11A alone is sufficient to rescue the phenotype of sickle cell disease (SCD). In September 2015, Orkin published a study in the journal Nature showing a small section of DNA which could be responsive to gene therapy for sickle-cell disease.[6] Translation of the basic findings on the role of BCL11A in HbF silencing to the clinic is ongoing both with gene therapy and therapeutic gene editing. Honors and awardsIn 1987, Orkin received the E. Mead Johnson Award.[7] Elected to the National Academy of Sciences in 1991, Orkin won the Jessie Stevenson Kovalenko Medal from that organization in 2013.[8] He was elected to the Institute of Medicine in 1992.[9] In 1993, he received the Warren Alpert Foundation Prize.[10] The American Society of Hematology named Orkin one of its Legends in Hematology in 2008.[11] The American Society of Human Genetics honored Orkin with the 2014 William Allan Award, which recognizes sustained and significant contributions to human genetics.[12] In 2017, he was elected to membership in the American Philosophical Society, and in 2018 he received the George M. Kober Medal of the American Association of Physicians and the Mechthild Esser Nemmers Prize in Medical Science from Northwestern University. PersonalOrkin has been married for more than 40 years and has one daughter.[1] References1. ^1 {{cite journal|last1=Kazazian|first1=Haig|title=2014 William Allan Award Introduction: Stuart Orkin|journal=American Journal of Human Genetics|date=March 2015|volume=96|issue=3|pages=352–353|doi=10.1016/j.ajhg.2014.11.018|pmc=4375625|pmid=25748350}} {{Authority control}}{{DEFAULTSORT:Orkin, Stuart}}2. ^{{cite web|title=Stuart H. Orkin, MD|url=http://www.dfhcc.harvard.edu/insider/member-detail/member/stuart-h-orkin-md/|publisher=Dana–Farber/Harvard Cancer Center|accessdate=November 11, 2015}} 3. ^{{cite web|title=Stuart Orkin, MD|url=http://hsci.harvard.edu/people/stuart-orkin-md|publisher=Harvard Stem Cell Institute|accessdate=November 11, 2015}} 4. ^{{cite web|title=Stuart H. Orkin, MD|url=http://www.hhmi.org/scientists/stuart-h-orkin|publisher=Howard Hughes Medical Institute|accessdate=November 11, 2015}} 5. ^{{cite web|title=BBS Faculty Member – Stuart Orkin|url=http://www.hms.harvard.edu/dms/bbs/fac/orkin.php|publisher=Harvard Medical School|accessdate=November 11, 2015}} 6. ^{{cite web|last1=Goldberg|first1=Carey|title=In step toward genetic fix, scientists pinpoint ‘Achilles heel’ of sickle cell disease|url=http://commonhealth.wbur.org/2015/09/sickle-cell-disease-genetic-fix|publisher=WBUR-FM|accessdate=November 11, 2015|date=September 21, 2015}} 7. ^{{cite web|title=E. Mead Johnson Award in Pediatric Research|url=https://www.aps-spr.org/SPR/Awards/EMJ/PastRecipients.asp|publisher=American Pediatric Society|accessdate=November 11, 2015}} 8. ^{{cite web|title=Stuart H. Orkin|url=http://www.nasonline.org/member-directory/members/18963.html?referrer=https://www.google.com/|publisher=National Academy of Sciences|accessdate=November 11, 2015}} 9. ^{{cite web|title=IOM Member- Stuart H. Orkin, M.D.|url=http://iom.nationalacademies.org/Global/Directory/Detail.aspx?id=0000018963|publisher=Institute of Medicine|accessdate=November 11, 2015}} 10. ^{{cite web|title=1993 Recipient: Stuart H. Orkin|url=http://www.warrenalpert.org/prize-recipients/stuart-h-orkin|publisher=Warren Alpert Foundation|accessdate=November 11, 2015}} 11. ^{{cite web|title=Legends in Hematology|url=http://www.hematology.org/About/History/Legends.aspx|publisher=American Society of Hematology|accessdate=November 11, 2015}} 12. ^1 2 {{cite web|title=ASHG honors Stuart H. Orkin with William Allan Award|url=http://www.ashg.org/press/201406-allan-award.html|publisher=American Society of Human Genetics|accessdate=November 11, 2015|date=June 26, 2014}} 13 : Living people|American hematologists|Stem cell researchers|Recipients of awards from the United States National Academy of Sciences|Massachusetts Institute of Technology alumni|Harvard Medical School alumni|Harvard Medical School faculty|Howard Hughes Medical Investigators|Members of the National Academy of Medicine|Fellows of the American Association for the Advancement of Science|Members of the American Philosophical Society|Members of the United States National Academy of Sciences|Year of birth missing (living people) |
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