| 词条 | TBPO |
| 释义 |
| ImageFile = TBPO.svg | ImageSize = 120px | IUPACName=4-tert-butyl-2,6,7-trioxa-1λ5-phosphabicyclo[2.2.2]octane 1-oxide | OtherNames= t-Butyl-bicyclophosphate | Name = TBPO[1] | Section1 = {{Chembox Identifiers | CASNo = 61481-19-4 | ChemSpiderID = 39799 | PubChem = 43673 | StdInChI=1S/C8H15O4P/c1-7(2,3)8-4-10-13(9,11-5-8)12-6-8/h4-6H2,1-3H3 | StdInChIKey = CNBZOKKOTFTYLW-UHFFFAOYSA-N | SMILES = CC(C)(C)C12COP(=O)(OC1)OC2 }} | Section2 = {{Chembox Properties | C=8|H=15|O=4|P=1 }} | Section3 = {{Chembox Hazards | MainHazards = Extremely toxic | LD50 = 36 μg/kg (mice) }} }}TBPO is an extremely toxic bicyclic phosphate convulsant and GABA receptor antagonist. It is the most toxic bicyclic phosphate known, with an {{LD50}} of 36 μg/kg in mice.[2] See also
References1. ^{{cite journal |last1=Zhao |first1=C. |last2=Hwang |first2=S. H. |last3=Buchholz |first3=B. A. |last4=Carpenter |first4=T. S. |last5=Lightstone |first5=F. C. |last6=Yang |first6=J. |last7=Hammock |first7=B. D. |last8=Casida |first8=J. E. |title=GABAA receptor target of tetramethylenedisulfotetramine |journal=Proceedings of the National Academy of Sciences |date=27 May 2014 |volume=111 |issue=23 |pages=8607–8612 |doi=10.1073/pnas.1407379111 |pmid=24912155 |pmc=4060666|bibcode=2014PNAS..111.8607Z }} {{Convulsants}}{{Neurotoxins}}{{GABA receptor modulators}}{{Neurotoxin-stub}}2. ^{{cite journal |last1=Milbrath |first1=Dean S. |last2=Engel |first2=Judith L. |last3=Verkade |first3=John G. |last4=Casida |first4=John E. |title=Structure-toxicity relationships of 1-substituted-4-alkyl-2,6,7-trioxabicyclo[2.2.2.]octanes |journal=Toxicology and Applied Pharmacology |date=February 1979 |volume=47 |issue=2 |pages=287–293 |doi=10.1016/0041-008x(79)90323-5}} 5 : Convulsants|Neurotoxins|Bicyclic phosphates|GABAA receptor negative allosteric modulators|Tert-butyl compounds |
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